Mass spectrometric analysis in combinatorial chemistry

Swali, Vinay; Langley, G. John; Bradley, Mark

doi:10.1016/s1367-5931(99)80050-7

Cited by 38 publications

(25 citation statements)

References 10 publications

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“…On the other hand, the introduction of semiautomatic combinatorial synthesis systems using microreactors, radio-frequency tagging and directed sorting, 233 as well as development of analytical and screening techniques, [234][235][236][237][238][239][240] helped to overpass the immense task of identifying and isolate the bioactive agents from large libraries. More recently, advances in genetic engineering allowed the manipulation of genes involved in microbial biosynthetic pathways, which led to the formation of novel natural-product like molecules, particularly, polyketides and macrolide antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Natural Product‐Like Combinatorial Libraries

Abreu

Branco

2004

ChemInform

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A química combinatorial emergiu ao longo dos últimos anos como uma importante ferramenta na pesquisa de moléculas pioneiras para a modelagem de novos fármacos. Nesta perspectiva, a diversidade estrutural e a vasta gama de propriedades biológicas exibidas pelos metabolitos secundários, constituem um desafio à implementação de estratégias combinatórias na síntese e derivatização de produtos naturais. Este artigo ilustra a aplicação das técnicas combinatórias no desenho e formação de bibliotecas baseadas em produtos naturais de diversa origem biossintética, e seus análogos estruturais.Combinatorial chemistry has emerged over the last few years as an important tool for drug discovery and lead optimisation. In this approach, the molecular diversity and range of biological properties displayed by secondary metabolites constitutes a challenge to combinatorial strategies for natural products synthesis and derivatization. This article surveys the application of combinatorial techniques to the design of "natural product-looking" libraries covering a wide range of structural diversities.

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Section: Discussionmentioning

confidence: 99%

Natural Product‐Like Combinatorial Libraries

Abreu

Branco

2004

ChemInform

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“…As the MS techniques [300,301] are becoming more sensitive and more readily available, more reports based on direct structure determination by MS/MS experiments are being published [302]. A single bead can even be physically cut into several pieces and still provide adequate quantities of peptides for this type of analysis [302,303].…”

Section: Determination Of the Structure Of A Peptide On An Individualmentioning

confidence: 99%

Combinatorial/Library Peptide Synthesis

Lebl

2011

Amino Acids, Peptides and Proteins in Organic Chemistry

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“…The synthesis of mixtures of compounds has required a concomitant advance in analytical capabilities that far exceed those required for single compound analysis. This revolution in new developments builds on traditional analytical techniques1–5 of which mass spectrometry (MS) is now proving to be the method of choice to couple with combinatorial chemistry 1,, 2. The impact of MS on combinatorial chemistry has recently been reviewed by two groups 1,, 2.…”

Section: Introductionmentioning

confidence: 99%

“…This revolution in new developments builds on traditional analytical techniques1–5 of which mass spectrometry (MS) is now proving to be the method of choice to couple with combinatorial chemistry 1,, 2. The impact of MS on combinatorial chemistry has recently been reviewed by two groups 1,, 2. In these reviews, the place of Fourier‐transform ion cyclotron resonance (FTICR) in the analysis of combinatorially generated compounds has been presented as a valuable but as yet unknown quantity, with just a small number of applications presented in the literature to date 6–8.…”

Section: Introductionmentioning

confidence: 99%

Electrospray ionisation Fourier-transform ion cyclotron resonance mass spectrometry of dynamic combinatorial libraries

Poulsen

Gates

Cousins

et al. 2000

Rapid Commun. Mass Spectrom.

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The use of electrospray ionisation Fourier-transform ion cyclotron resonance tandem mass spectrometry (ESI-FTICR-MS/MS) for the analysis of dynamic combinatorial libraries (DCLs) of pseudo-peptide macrocyclic hydrazone oligomers is presented. The design of library building blocks results in mixtures of compounds with greater diversity than libraries generated by conventional combinatorial chemistry and so presents increased demands for analysis. The extended capabilities of the FTICR technique, specifically selective ion trapping, sensitivity, high resolution and mass accuracy over a broad mass range, are compatible with these increased demands and, most importantly, without the need for chromatography. Preliminary studies on the sequencing of cyclic oligomers and confirmation of the presence of sequence isomers are presented. These studies highlight the potential of FTICR-MS as a superior technique for the analysis of combinatorially generated compounds.

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Mass spectrometric analysis in combinatorial chemistry

Cited by 38 publications

References 10 publications

Natural Product‐Like Combinatorial Libraries

Natural Product‐Like Combinatorial Libraries

Combinatorial/Library Peptide Synthesis

Electrospray ionisation Fourier-transform ion cyclotron resonance mass spectrometry of dynamic combinatorial libraries

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