2019
DOI: 10.1002/mas.21590
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Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Abstract: This review describes the mass spectral fragmentation of trimethylsilyl (TMS) and related alkylsilyl derivatives used for preparing samples for analysis, mainly by combined gas chromatography and mass spectrometry (GC/MS). The review is divided into three sections. The first section is concerned with the TMS derivatives themselves and describes fragmentation of derivatized alcohols, thiols, amines, ketones, carboxylic acids and bifunctional compounds such as hydroxy‐ and amino‐acids, halo acids and hydroxy eth… Show more

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Cited by 42 publications
(78 citation statements)
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“…28 In contrast to an earlier described method for 18 oxygen exchange, while the acid catalysis method showed a strong dependence of exchange rates on the temperature and steric environment of the carbonyl group. Using acid-catalyzed labelling for 4-ene-3-ones such as testosterone, for example, a reaction time of 72 h was needed until the desired equilibrium was achieved, while the exchange procedure described herein only required less than 2 h. To obtain 18 O-labelled hydroxy groups, the labelled oxo steroids were reduced with NaBH 4 (Figure 1). Generally, these losses are considered to be rather unspecific and an explanation of their exact formation and their origin is rarely given.…”
Section: Derivatizationmentioning
confidence: 70%
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“…28 In contrast to an earlier described method for 18 oxygen exchange, while the acid catalysis method showed a strong dependence of exchange rates on the temperature and steric environment of the carbonyl group. Using acid-catalyzed labelling for 4-ene-3-ones such as testosterone, for example, a reaction time of 72 h was needed until the desired equilibrium was achieved, while the exchange procedure described herein only required less than 2 h. To obtain 18 O-labelled hydroxy groups, the labelled oxo steroids were reduced with NaBH 4 (Figure 1). Generally, these losses are considered to be rather unspecific and an explanation of their exact formation and their origin is rarely given.…”
Section: Derivatizationmentioning
confidence: 70%
“…Prior to GC/MS analyses, residues were derivatized with 90 μL 18 O-oxo groups (Figure 1). This fast and targeted method has also successfully been used in our group for other compounds such as benzophenone derivatives.…”
Section: Derivatizationmentioning
confidence: 99%
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