Mass spectrometric study of cyclodepsipeptides

Purification and characterization of roseotoxin B, a toxic cyclodepsipeptide from Trichothecium roseum

“…b Percentage of base peak ( m / e 86). minus 57 or C3H7N (from N-methylalanine), and the m / e 506 ion is 591 minus 85 or CbH11N from the isoleucyl or N-methylvalyl residue by the morpholine fragmentation route (Wulfson et al, 1964). The m / e 478 ion is 591 minus 113 or CsHllON (isoleucyl or N-methylvalyl residue), and the 421 ion is 534 minus 113 or CeHllON as above.…”

“…Fragmentation patterns of cyclodepsipeptides have been studied by Wulfson et al (1964Wulfson et al ( , 1965. The most important fragmentation pattern for roseotoxin B, an irregular cyclohexadepsipeptide, is the morpholine type.…”

The History of the Mass Spectrometry of Peptides and Proteins in the USSR

“…Puchkov. 8 The cyclodepsipeptide ionofores are the atypical natural peptides built from amino and hydroxy acid residues combined via the amide and ester bonds. Many antibiotics, toxins and alkaloids belong to this class of compounds.…”

Oxygen-, nitrogen-, and sulfur-substituted heteroallenes

“…This indicates that different mechanisms may be involved in the cyclization step,31 an alternative pathway being the formation of a salt with a structure like 41 which has been proposed as intermediate in the lactam-formation using cyanoacetyl chloride. 39…”