Mass Spectrometry as a Crucial Analytical Basis for Omics Sciences

Заикин, В. Г.; Борисов, Р. С.

doi:10.1134/s1061934821140094

Cited by 17 publications

(15 citation statements)

References 170 publications

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“…The aforementioned studies highlight the power of GC-MS as an analytical tool for identifying commercially viable, bioactive and therapeutic molecules from plant extracts. For the avid reader, we recommend the state-of-the-art of the literature on GC-MS [ 221 , 222 , 223 ].…”

Section: Methodsmentioning

confidence: 99%

Extraction of High-Value Chemicals from Plants for Technical and Medical Applications

Kapadia

Newell

Cunningham³

et al. 2022

IJMS

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Plants produce a variety of high-value chemicals (e.g., secondary metabolites) which have a plethora of biological activities, which may be utilised in many facets of industry (e.g., agrisciences, cosmetics, drugs, neutraceuticals, household products, etc.). Exposure to various different environments, as well as their treatment (e.g., exposure to chemicals), can influence the chemical makeup of these plants and, in turn, which chemicals will be prevalent within them. Essential oils (EOs) usually have complex compositions (>300 organic compounds, e.g., alkaloids, flavonoids, phenolic acids, saponins and terpenes) and are obtained from botanically defined plant raw materials by dry/steam distillation or a suitable mechanical process (without heating). In certain cases, an antioxidant may be added to the EO (EOs are produced by more than 17,500 species of plants, but only ca. 250 EOs are commercially available). The interesting bioactivity of the chemicals produced by plants renders them high in value, motivating investment in their production, extraction and analysis. Traditional methods for effectively extracting plant-derived biomolecules include cold pressing and hydro/steam distillation; newer methods include solvent/Soxhlet extractions and sustainable processes that reduce waste, decrease processing times and deliver competitive yields, examples of which include microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), subcritical water extraction (SWE) and supercritical CO2 extraction (scCO2). Once extracted, analytical techniques such as chromatography and mass spectrometry may be used to analyse the contents of the high-value extracts within a given feedstock. The bioactive components, which can be used in a variety of formulations and products (e.g., displaying anti-aging, antibacterial, anticancer, anti-depressive, antifungal, anti-inflammatory, antioxidant, antiparasitic, antiviral and anti-stress properties), are biorenewable high-value chemicals.

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Section: Methodsmentioning

confidence: 99%

Extraction of High-Value Chemicals from Plants for Technical and Medical Applications

Kapadia

Newell

Cunningham³

et al. 2022

IJMS

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“…截至目前, 化学衍生化技术已在分析化学领域中得到了广泛应用 [76][77][78][79] . 该技术通过衍生化试剂相关反应基团与靶向待测分子特定官能团发生衍生化反应促使样品分子化学结构发生一定变化, 从而改变后者理化性质, 用以提高分析效能 [80,81] . 化学衍生化试剂通常包括反应基团与修饰基团两部分.…”

Section: 化学衍生化技术unclassified

Chemical derivatization: recent advances in mass spectrometry imaging

Li¹,

Qin²,

Jiang³

et al. 2022

Sci. Sin.-Chim

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Recently, mass spectrometry imaging (MSI) has been drawing more and more attention due to its continuous development and improvement as well as its vital role in the study of biological science. Many MSI-based strategies have been widely applied to the in situ qualitative and quantitative detection and imaging of endogenous/exogenous molecules in tissues. Among, matrix assisted laser desorption/ionization MSI (MALDI-MSI) and desorption electrospray ionization MSI (DESI-MSI) are generally regarded as two the most commonly used molecular imaging techniques. Although MSI, as a histology-based emerging molecular imaging technique, has significant advantages over other imaging techniques because it is a label-free technique which provides high sensitivity, high throughput, and molecular specificity derived from the use of mass spectrometers as detectors for a wide variety of ionized biomolecules in situ within a tissue section, it still has obvious shortcomings in the in situ analysis of low-polarity and neutral biomolecules. To solve this issue, the application of chemical derivatization technology in MSI is one of the most important approaches to overcome these deficiencies of MS molecular imaging. This review provides an overview of various chemical derivatization techniques, such as, esterification derivatization, acylation derivatization, addition reaction derivatization, substitution derivatization, oxidative derivatization, and other derivatizations, used in MS analysis, highlights the application of these chemical derivatization methods in the in situ detection and imaging of biomolecules in tissues by MALDI-MSI and DESI-MSI. It can be predicted that with the advance progress of chemical derivatization technology, the application scope of MSI will be further expanded in the fields of spatial metabolomics, spatial lipidomics, spatial proteomics, and spatial glycomics.

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“…Approaches based on MS and steered to answering the problems of petroleomics, foodomics, and economics; or those problems related to inorganic sciences -are merely mentioned. The most compelling consideration is paid to "OMICS" related to the life sciences as those represent the majority of today's "OMICS [2]. Notwithstanding this explanation, there are "OMICS" outside of the life sciences circle.…”

Section: "Omics"mentioning

confidence: 99%

“…One of the universally used -powerful and flexible tools of any laboratory is actually a hybrid of gas chromatography (GC) and mass spectrometry (MS). MS is one of the main analytical technologies on which the ''-omics'' approaches are based [1,2]. emerging concept of OMICS 2.0 pushes it even further into the foreground [3,4].…”

Section: Introductionmentioning

confidence: 99%

Mass Spectrometry-Based Techniques Towards OMICS 2.0

Šoša¹

2022

Preprint

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The literature was scoped to help place mass spectrometric (MS) platforms in the spotlight of the life sciences, as a tool of OMICS and OMICS 2.0 technologies. These methods were discussed, and their feasibility was highlighted in many reviews that have been periodically published, in addition to the most recently developed term OMICS 2.0. This author’s primary interest was the forensic application of MS, but since these interests got broadened, terms such as “biosensors” were also included. So, means of discovery of efficient biomarkers and clinical therapeutic targets were also reviewed. However, within the framework of this review, physical chemistry, bioinformatics, or specific software solutions were not specifically scoped. Aside from simply reviewing the research status and the future perspectives, this article tackles terms such as Society 5.0 and OMICS 2.0. Since the topic of generating permanent collections of digital content for retrospective analysis was reviewed, what requires loads of data – cloud storage is discussed in the context of MS. In this manner, the review has strengthened an in-depth understanding of the applications of MS. These large quantities of data are easier to operate with if generated by MS, rather than by any other commercially available assay.

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Mass Spectrometry as a Crucial Analytical Basis for Omics Sciences

Cited by 17 publications

References 170 publications

Extraction of High-Value Chemicals from Plants for Technical and Medical Applications

Extraction of High-Value Chemicals from Plants for Technical and Medical Applications

Chemical derivatization: recent advances in mass spectrometry imaging

Mass Spectrometry-Based Techniques Towards OMICS 2.0

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