Mass spectrometry-based analysis of gut microbial metabolites of aromatic amino acids

Jariyasopit, Narumol; Khoomrung, Sakda

doi:10.1016/j.csbj.2023.09.032

Cited by 5 publications

(1 citation statement)

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Proteins that escape digestion reach the colonic lumen, where they serve as fermentable substrates for the gut microbiota and undergo proteolysis into amino acids. Colonic amino acids may be further metabolized by the gut microbiota, as exemplified by aromatic amino acids (AAAs) [21]. AAA catabolism by the gut microbiome yields numerous metabolites that can regulate immune, metabolic, and neuronal responses at local and distant sites.…”

Section: Introductionmentioning

confidence: 99%

Microbiota Metabolite Profiles and Dietary Intake in Older Individuals with Insomnia of Short vs. Normal Sleep Duration

Even,

Magzal,

Shochat

et al. 2024

Biomolecules

View full text Add to dashboard Cite

Recent evidence suggests that the gut microbiota plays a role in insomnia pathogenesis. This study compared the dietary habits and microbiota metabolites of older adults with insomnia of short vs. normal sleep duration (ISSD and INSD, respectively). Data collection included sleep assessment through actigraphy, dietary analysis using the Food Frequency Questionnaire, and metabolomic profiling of stool samples. The results show that ISSD individuals had higher body mass index and a greater prevalence of hypertension. Significant dietary differences were observed, with the normal sleep group consuming more kilocalories per day and specific aromatic amino acids (AAAs) phenylalanine and tyrosine and branch-chain amino acid (BCAA) valine per protein content than the short sleep group. Moreover, metabolomic analysis identified elevated levels of the eight microbiota metabolites, benzophenone, pyrogallol, 5-aminopental, butyl acrylate, kojic acid, deoxycholic acid (DCA), trans-anethole, and 5-carboxyvanillic acid, in the short compared to the normal sleep group. The study contributes to the understanding of the potential role of dietary and microbial factors in insomnia, particularly in the context of sleep duration, and opens avenues for targeted dietary interventions and gut microbiota modulation as potential therapeutic approaches for treating insomnia.

show abstract

Section: Introductionmentioning

confidence: 99%

Microbiota Metabolite Profiles and Dietary Intake in Older Individuals with Insomnia of Short vs. Normal Sleep Duration

Even,

Magzal,

Shochat

et al. 2024

Biomolecules

View full text Add to dashboard Cite

show abstract

Recent updates on diet‐derived gut microbial metabolites

Prasain,

Barnes

2024

eFood

View full text Add to dashboard Cite

Emerging evidence indicates that the health‐beneficial effects of ingested food components depend on in part, their upper and lower gastrointestinal uptake and metabolism and the gut microbial composition of the host. Several dietary components, such as polyphenols, are poorly absorbed in the upper intestinal compartments and extensively metabolized by the colonic microbiota resulting in the production of an array of metabolites. These microbiota‐mediated products possess specific solubility, reactivity, bioavailability, and biological activities. However, identifying and characterizing a wide range of metabolites is challenging due to the high chemical diversity of dietary components and interindividual variability of the gut microbiota. It is, therefore, critical to design an animal model that effectively mimics human microbial metabolism and use multidisciplinary omics approaches such as metabolomics to detect and identify a wide range of metabolites. Here, we provide the current state of knowledge of major diet‐derived gut microbial metabolites and their potential biological activities.

show abstract

Epigenetic Modulations by Microbiome in Breast Cancer

Zhao,

Bhatnagar

2024

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Mass spectrometry-based analysis of gut microbial metabolites of aromatic amino acids

Cited by 5 publications

References 91 publications

Microbiota Metabolite Profiles and Dietary Intake in Older Individuals with Insomnia of Short vs. Normal Sleep Duration

Microbiota Metabolite Profiles and Dietary Intake in Older Individuals with Insomnia of Short vs. Normal Sleep Duration

Recent updates on diet‐derived gut microbial metabolites

Epigenetic Modulations by Microbiome in Breast Cancer

Contact Info

Product

Resources

About