2021
DOI: 10.1039/d1sc00271f
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Mass spectrometry-based chemical mapping and profiling toward molecular understanding of diseases in precision medicine

Abstract: An overview of MS-based chemical mapping and profiling, indicating its contributions to the molecular understanding of diseases in precision medicine by answering "what", "where", "how many" and "whose” chemicals underlying clinical phenotypes.

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Cited by 18 publications
(10 citation statements)
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“…To date, a variety of mass tags have been used for quantitative detection, such as peptides, small molecules, and metal ions. 24 Among them, well-designed peptides can have both sequence uniqueness to avoid overlapping with endogenous peptides and sufficient mass spectrometric response for quantification. 33 Notably, several peptide mass tags have been frequently employed in our previous work.…”
Section: Resultsmentioning
confidence: 99%
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“…To date, a variety of mass tags have been used for quantitative detection, such as peptides, small molecules, and metal ions. 24 Among them, well-designed peptides can have both sequence uniqueness to avoid overlapping with endogenous peptides and sufficient mass spectrometric response for quantification. 33 Notably, several peptide mass tags have been frequently employed in our previous work.…”
Section: Resultsmentioning
confidence: 99%
“…Mass-tagged probes usually contain a recognition part to capture the target, a mass tag for quantification, and a cleavable linker for tag release. The released mass tag is ultimately quantified by mass spectrometry, and its amount represents the level of the target . For protein dimer detection, it is not enough to simply quantify each protein monomer.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The detection probe also has the HB5 aptamer as the recognition part. Moreover, the mass tag in this probe played an essential role in converting the protein information to the MS signal . Among a wide variety of mass tags, well-designed peptides have gained more interest because they have both unique sequence to avoid overlapping with endogenous peptides and sufficient mass spectrometric signal for quantitative analysis .…”
Section: Resultsmentioning
confidence: 99%
“… 18 Thus, a lengthy culture-enrichment step is often required prior to MS detection. 19 Fortunately, among various MS-based approaches, the one relying on mass-tagged probes and liquid chromatography-tandem mass spectrometry (LC-MS/MS) can convert and amplify the signal of the target molecule into that of mass tags such as peptides, which has significantly expanded the application of MS. 20 Moreover, mass-tagged probes can convert the signal of each target molecule into that of multiple mass tag molecules using signal amplification strategies. 21 Notably, multiple signal amplification strategies may be required for the detection of ultralow abundant target molecules such as DRB.…”
Section: Introductionmentioning
confidence: 99%