Mass spectrometry-based urinary metabolomics for the investigation on the mechanism of action of Eleutherococcus senticosus (Rupr. &amp; Maxim.) Maxim. leaves against ischemic stroke in rats

Wang, Rongjin; Shi, Liqiang; Liu, Shu; Liu, Zhiqiang; Song, Fengrui; Sun, Zhiheng; Liu, Zhongying

doi:10.1016/j.jep.2019.111969

Cited by 28 publications

(17 citation statements)

References 41 publications

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“…E. senticosus is popularly known as the Siberian ginseng because of its remarkable pharmacological effects, which can be used as a tonic and sedative and to treat rheumatism and diabetes (Umeyama et al 1992). The main activities of E. senticosus are contains flavonoids, organic acids, phenols, triterpenoid saponins, lignans, coumarins, polysaccharides and other compounds (Wang et al 2019). E. senticosus has been widely as an herb medicine used to treat neurasthenia, hypertension, immune regulation, cerebrovascular diseases and ischemic heart disease in China (Wang et al 2019).…”

Section: Eleutherococcus Senticosus; Chloroplast Genome; Genomics; Phmentioning

confidence: 99%

“…The main activities of E. senticosus are contains flavonoids, organic acids, phenols, triterpenoid saponins, lignans, coumarins, polysaccharides and other compounds (Wang et al 2019). E. senticosus has been widely as an herb medicine used to treat neurasthenia, hypertension, immune regulation, cerebrovascular diseases and ischemic heart disease in China (Wang et al 2019). Here, the complete chloroplast genome of E. senticosus was completed, which can be useful to study this species phylogenetic relationship and also can provide more genomics information for further research on the herb species in China.…”

Section: Eleutherococcus Senticosus; Chloroplast Genome; Genomics; Phmentioning

confidence: 99%

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Characterization of the complete chloroplast genome of Eleutherococcus senticosus (Araliaceae) as an herb in China

Tian

2020

Mitochondrial DNA Part B

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Eleutherococcus senticosus is a highly valued woody herb medicinal plant belonging to the family Araliaceae, which is also the popular edible plant in China. In this paper, the chloroplast genome of E. senticosus was completed. The complete chloroplast genome of E. senticosus was 156,768 bp in length as a circle. It contained a large single-copy (LSC) region of 86,756 bp, a small single-copy (SSC) region of 18,154 bp and separated by two inverted repeat (IR) regions of 25,929 bp. The base compositions of chloroplast genome is uneven and the overall nucleotide composition is: A (30.7%), T (31.4%), C (19.3%) and G (18.6%), with a total G þ C content (39.4%). It comprised 134 genes, including 89 protein-coding genes (PCGs), 37 transfer RNA (tRNA) genes and 8 ribosomal RNA (rRNA) genes. 8 PCG genes species, 7 tRNA genes species and 4 rRNA species were found duplicated in the IR regions. The phylogenetic analysis result shown that the chloroplast genome of E. senticosus is closest to Eleutherococcus sessiliflorus of the family Araliaceae in this study by the maximum-likelihood (ML) method. The complete chloroplast genome of E. senticosus can provide more genomics information for further research on the species in China.

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Section: Eleutherococcus Senticosus; Chloroplast Genome; Genomics; Phmentioning

confidence: 99%

Section: Eleutherococcus Senticosus; Chloroplast Genome; Genomics; Phmentioning

confidence: 99%

Characterization of the complete chloroplast genome of Eleutherococcus senticosus (Araliaceae) as an herb in China

Tian

2020

Mitochondrial DNA Part B

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“…It is characterized by sudden onset, high risk of disease, high mortality rate, and long-term disability, which brings a severe burden to the normal life of individuals and the cost of the medical care system ( Liu R. et al, 2020 ). With about 15 million cases occurring every year ( Manwani and McCullough, 2013 ) and a 30% mortality rate, CI is regarded as the third leading cause of death and a major cause of disability worldwide ( Wang R. et al, 2019 ). The patients of CI should be diagnosed rapidly and treated promptly and appropriately; otherwise, it is very difficult to cure.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Chinese Herbal Medicine for Cerebral Ischemic Reperfusion Injury

et al. 2022

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Cerebral ischemic reperfusion injury (CI/RI) is a critical factor that leads to a poor prognosis in patients with ischemic stroke. It is an extremely complicated pathological process that is clinically characterized by high rates of disability and mortality. Current available treatments for CI/RI, including mechanical and drug therapies, are often accompanied by significant side effects. Therefore, it is necessary to discovery new strategies for treating CI/RI. Many studies confirm that Chinese herbal medicine (CHM) was used as a potential drug for treatment of CI/RI with the advantages of abundant resources, good efficacy, and few side effects. In this paper, we investigate the latest drug discoveries and advancements on CI/RI, make an overview of relevant CHM, and systematically summarize the pathophysiology of CI/RI. In addition, the protective effect and mechanism of related CHM, which includes extraction of single CHM and CHM formulation and preparation, are discussed. Moreover, an outline of the limitations of CHM and the challenges we faced are also presented. This review will be helpful for researchers further propelling the advancement of drugs and supplying more knowledge to support the application of previous discoveries in clinical drug applications against CI/RI.

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“…The consumption of A. senticosus root, the most common way, is increasingly replaced by its leaf due to the similar effect. As a renewable resource, A. senticosus leaf has the potential to be an alternative resource (Wang et al 2019a).…”

Section: Introductionmentioning

confidence: 99%

“…According to Chinese Pharmacopoeia, A. senticosus is a well-known traditional Chinese medicine for applications such as kidney tonifying and tranquilization (Zhang et al 2020). The main active medicinal components of A. senticosus, such as triterperoid, saponins, lignans, avones and phenolic compounds, are derived from all parts of the plant (Wang et al 2019a;Chen et al 2020a). As one of the main active medicinal components of A. senticosus, eleutheroside B has anti-diabetic, antifatigue, sleep-enhancement, neuro-protection and antioxidant effects.…”

Section: Introductionmentioning

confidence: 99%

Tissue-Specific Metabolic Response of Acanthopanax Senticosus (Rupr. Et. Maxim.) Harms Leaf To UV-B radiation

Liu

Yang

et al. 2021

Preprint

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This study aims to evaluate the effects of medium and high UV-B radiation on leaves of Acanthopanax senticosus (Rupr. et. Maxim.) Harms. Two-year-old potted A. senticosus plant samples were respectively exposed to two levels of artificial, biologically effective UV-B radiation under glasshouse-controlled conditions: 1.972KJ/m2 and 3.442KJ/m2. Ordinary sunlight treatment was included as a control group, in which major effects of UV-B were observed. It was discovered that UV-B enhanced the medicinal value (especially eleutheroside B and E) of A. senticosus but impaired its growth. The sensitivity of leaves to UV-B radiation varied across different parts of the plant, among which the upper leaves responded most strongly. Furthermore, multiple types of phenolic compounds are synergistically involved in stress resistance in different aspects, including up-regulation of UV-absorbing substances (C6C3C6-type, kaempferol and rutin) and antioxidant enzyme synergists (C6C1-type, salicylic acid) as well as down-regulation of antioxidants (C6C3-type, p-coumaric acid). Conclusion of this study may provide a new perspective to improve the exploitation of A. senticosus.

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Mass spectrometry-based urinary metabolomics for the investigation on the mechanism of action of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves against ischemic stroke in rats

Cited by 28 publications

References 41 publications

Characterization of the complete chloroplast genome of Eleutherococcus senticosus (Araliaceae) as an herb in China

Characterization of the complete chloroplast genome of Eleutherococcus senticosus (Araliaceae) as an herb in China

Recent Advances in Chinese Herbal Medicine for Cerebral Ischemic Reperfusion Injury

Tissue-Specific Metabolic Response of Acanthopanax Senticosus (Rupr. Et. Maxim.) Harms Leaf To UV-B radiation

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