Mass spectrometry characterization of Commiphora leptophloeos leaf extract and preclinical evaluation of toxicity and anti-inflammatory potential effect

Dantas-Medeiros, Renato; Furtado, Allanny Alves; Zanatta, Ana C.; Torres-Rêgo, Manoela; Lourenço, Estela Mariana Guimarães; Alves, Jovelina Samara Ferreira; Ferreira, Éder G.; Rocha, Hugo Alexandre de Oliveira; Guerra, Gerlane Coelho Bernardo; Vilegas, Wagner; Araújo, Thiago Antǒnio de Sousa; Fernandes-Pedrosa, Matheus de Freitas; Zucolotto, Silvana Maria

doi:10.1016/j.jep.2020.113229

Cited by 24 publications

(13 citation statements)

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“…Therefore, it is thought that the inhibition of multiple cytochrome P450 enzymes is related to the presence of phenolic compounds such as phenolic acids and flavonoids in S. europaea [ 3 ]. The application of mass spectrometry techniques in preclinical investigations and to evaluate the potential biologically active compounds in halophytic plants is encouraged for future studies [ 109 ].…”

Section: Anti-inflammatory and Antimicrobial Activities Of The Three Halophytesmentioning

confidence: 99%

Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms

et al. 2021

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The pharmacological activities in bioactive plant extracts play an increasing role in sustainable resources for valorization and biomedical applications. Bioactive phytochemicals, including natural compounds, secondary metabolites and their derivatives, have attracted significant attention for use in both medicinal products and cosmetic products. Our review highlights the pharmacological mode-of-action and current biomedical applications of key bioactive compounds applied as anti-inflammatory, bactericidal with antibiotics effects, and pain relief purposes in controlled clinical studies or preclinical studies. In this systematic review, the availability of bioactive compounds from several salt-tolerant plant species, mainly focusing on the three promising species Aster tripolium, Crithmum maritimum and Salicornia europaea, are summarized and discussed. All three of them have been widely used in natural folk medicines and are now in the focus for future nutraceutical and pharmacological applications.

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Section: Anti-inflammatory and Antimicrobial Activities Of The Three Halophytesmentioning

confidence: 99%

Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms

et al. 2021

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Section: Resultsmentioning

confidence: 99%

“…6A). When evaluated, the progression of the edema after the 4 h of observation, calculated through the area under the curve of edema kinetics using the trapezoidal rule (26,28), showed a significant decrease in all doses of PA-Int5 tested when compared with the carrageenan group [ In the zymosan-induced air-pouch model, treatment with zymosan significantly increased leukocyte migration compared with the PBS group. PA-Int5, at all doses tested, significantly inhibited the migration of leukocytes into the dorsal cavity, when compared with the zymosan group, as shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The area under the time-course curve was also determined using the trapezoidal rule ( 26 , 28 ).…”

Section: Methodsmentioning

confidence: 99%

“…Animals were injected ipl with 50 µl 1% λ-carrageenan (Sigma-Aldrich; Merck KGaA) or PBS (pH 7.4). A total of 50 µl is recommended for the formation of edema in the paw, being a more standardized way of evaluating edema in this experimental model, as used in previous studies (27)(28)(29)(30).…”

Section: Evaluation Of Anti-inflammatory Activitymentioning

confidence: 99%

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PA‑Int5: An isatin‑thiosemicarbazone derivative that exhibits anti‑nociceptive and anti‑inflammatory effects in Swiss mice

et al. 2021

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Pain and inflammation are symptoms of various diseases, and they can be modulated by different pathways, thus highlighting the importance of investigating the therapeutic effects of novel compounds. Previous studies have shown that isatin-thiosemicarbazone exhibits antitumor, antifungal antibacterial and other biological properties. Based on the wide range of biological effects of these compounds, the aim of the present study was to investigate the central nervous system (CNS) performance, and the anti-nociceptive and anti-inflammatory activity of (Z)-2-(5-nitro-2-oxoindolin-3-ilidene)-N-hydroazinecarbothioamide (PA-Int5) in treated mice. Three doses of PA-Int5 were tested orally (1.0, 2.5 and 5.0 mg/kg) in the nociceptive and inflammatory animal models. Additionally, the potential sedative effects of PA-Int5 (5 mg/kg, oral gavage) were investigated using an open ﬁeld and rotarod tests, to exclude any possible unspecific effects of the nociceptive assays. Anti-nociceptive activity was assessed using the acetic acid-induced abdominal contortion and formalin tests, whereas anti-inflammatory activity was assessed using a carrageenan-induced paw edema and zymosan-induced air-pouch models. PA-Int5 (5 mg/kg) induced anti-nociceptive activity in the abdominal contortion model. In the formalin test, PA-Int5 (at 2.5 and 5 mg/kg) reduced nociception in the second phase. At the higher dose tested, PA-Int5 did not affect spontaneous locomotion or motor coordination. The data revealed that at all doses tested, the compound significantly reduced paw edema following carrageenan administration. In the zymosan-induced air-pouch model, PA-Int5 potently inhibited leukocyte migration and protein levels at the site of inflammation. When combined, the results revealed, for the first time, that PA-Int5 exhibited anti-nociceptive and anti-inflammatory activities, and highlights its potential, as well that of other derivatives, as novel candidates for pain relief.

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Antiophidic potential of chlorogenic acid and rosmarinic acid against Bothrops leucurus snake venom

Silva

Ferreira

Torres-Rêgo

et al. 2022

Biomedicine & Pharmacotherapy

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Mass spectrometry characterization of Commiphora leptophloeos leaf extract and preclinical evaluation of toxicity and anti-inflammatory potential effect

Cited by 24 publications

References 49 publications

Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms

Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms

PA‑Int5: An isatin‑thiosemicarbazone derivative that exhibits anti‑nociceptive and anti‑inflammatory effects in Swiss mice

Antiophidic potential of chlorogenic acid and rosmarinic acid against Bothrops leucurus snake venom

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