Mass spectrometry detection of minor new meridianins from the antarctic colonial ascidians<i>Aplidium falklandicum</i>and<i>Aplidium meridianum</i>

Núñez-Pons, Laura; Nieto, Rosa M.; Ávila, Conxita; Jiménez, Carlos; Rodrı́guez, Jaime

doi:10.1002/jms.3502

Cited by 14 publications

(10 citation statements)

References 23 publications

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“…Over the last years, a large number of new metabolites have been described from Antarctic benthic invertebrates, either by our group (e.g. [37,[41][42][43][44][45][46][47][48][49][50]) or by others (e.g. [11,12,38,39]), thus showing a high chemical diversity too.…”

Section: Future Research Lines In Antarcticamentioning

confidence: 89%

Ecological and Pharmacological Activities of Antarctic Marine Natural Products

Ávila¹

2016

Planta Med

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Antarctic benthic communities are regulated by abundant interactions of different types among organisms, such as predation, competition, etc. Predators are usually sea stars, with omnivorous habits, as well as other invertebrates. Against this strong predation pressure, many organisms have developed all sorts of defensive strategies, including chemical defenses. Natural products are thus quite common in Antarctic organisms with an important ecological and pharmacological potential. In this paper, the chemical defenses of the Antarctic organisms studied during the ECOQUIM and ACTIQUIM projects, as well as their pharmacological potential, are reviewed. For the ecological defenses, predation against the sea star Odontaster validus is analyzed and evaluated along depth gradients as well as considering the lifestyle of the organisms. For the pharmacological activity, the anticancer, anti-inflammatory, and antibacterial activities tested are evaluated here. Very often, only crude extracts or fractions have been tested so far, and therefore, the natural products responsible for such activities remain yet to be identified. Even if the sampling efforts are not uniform along depth, most ecologically active organisms are found between 200 and 500 m depth. Also, from the samples studied, about four times more sessile organisms possess chemical defenses against the sea star than the vagile ones; these represent 50 % of sessile organisms and 35 % of the vagile ones, out of the total tested, being active. Pharmacological activity has not been tested uniformly in all groups, but the results show that relevant activity is found in different phyla, especially in Porifera, Cnidaria, Bryozoa, and Tunicata, but also in others. No relationship between depth and pharmacological activity can be established with the samples tested so far. More studies are needed in order to better understand the ecological relationships among Antarctic invertebrates mediated by natural products and to fully explore their pharmacological potential.

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Section: Future Research Lines In Antarcticamentioning

confidence: 89%

Ecological and Pharmacological Activities of Antarctic Marine Natural Products

Ávila¹

2016

Planta Med

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“…Meridianins ( Figure 3) are brominated 3-(2-aminopyrimidine)-indoles isolated from the ascidian Aplidium meridianum [35]. As they are structurally similar to variolins, meridianins are identified as a promising kinase-inhibitory scaffold, which inhibits various protein kinases, such as CDKs, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases, and casein kinase.…”

Section: Meridianinsmentioning

confidence: 99%

Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts

Dou

Dong

2019

Marine Drugs

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Marine ascidians are becoming important drug sources that provide abundant secondary metabolites with novel structures and high bioactivities. As one of the most chemically prolific marine animals, more than 1200 inspirational natural products, such as alkaloids, peptides, and polyketides, with intricate and novel chemical structures have been identified from ascidians. Some of them have been successfully developed as lead compounds or highly efficient drugs. Although numerous compounds that exist in ascidians have been structurally and functionally identified, their origins are not clear. Interestingly, growing evidence has shown that these natural products not only come from ascidians, but they also originate from symbiotic microbes. This review classifies the identified natural products from ascidians and the associated symbionts. Then, we discuss the diversity of ascidian symbiotic microbe communities, which synthesize diverse natural products that are beneficial for the hosts. Identification of the complex interactions between the symbiont and the host is a useful approach to discovering ways that direct the biosynthesis of novel bioactive compounds with pharmaceutical potentials.

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“…Mass spectrometric analysis of two antarctic ascidians led to the detection of 13 new meridianin analogs along with two dimers of meridianins B or E and A [ 133 ]. The search for new structures could provide more active forms for the development of potential drugs from this important family of kinase inhibiting alkaloids.…”

Section: Alkaloidsmentioning

confidence: 99%

Ascidian Toxins with Potential for Drug Development

Watters

2018

Marine Drugs

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Ascidians (tunicates) are invertebrate chordates, and prolific producers of a wide variety of biologically active secondary metabolites from cyclic peptides to aromatic alkaloids. Several of these compounds have properties which make them candidates for potential new drugs to treat diseases such as cancer. Many of these natural products are not produced by the ascidians themselves, rather by their associated symbionts. This review will focus mainly on the mechanism of action of important classes of cytotoxic molecules isolated from ascidians. These toxins affect DNA transcription, protein translation, drug efflux pumps, signaling pathways and the cytoskeleton. Two ascidian compounds have already found applications in the treatment of cancer and others are being investigated for their potential in cancer, neurodegenerative and other diseases.

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Mass spectrometry detection of minor new meridianins from the antarctic colonial ascidiansAplidium falklandicumandAplidium meridianum

Cited by 14 publications

References 23 publications

Ecological and Pharmacological Activities of Antarctic Marine Natural Products

Ecological and Pharmacological Activities of Antarctic Marine Natural Products

Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts

Ascidian Toxins with Potential for Drug Development

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