Mass spectrometry imaging: new eyes on natural products for drug research and development

Natural or artificial: An example of topographic spatial distribution analysis of mescaline in cactus plants by matrix-assisted laser desorption/ionization mass spectrometry imaging

“…Most of the current methods used for detecting mescaline are typical analytical methods, such as gas chromatography-mass spectrometry (GC-MS) (Henry et al, 2003;Pa ́lenı ́cek et al, 2008;Gambelunghe et al, 2013) and liquid chromatography-mass spectrometry (LC-MS) (Kikura-Hanajiri et al, 2005;Sergi et al, 2013;Boumba et al, 2017). Researchers have used qualitative and quantitative analyses of the target compounds in different sampling areas to deduce the spatial distribution of the target compounds in the whole plant.In recent years, mass spectrometry imaging (MSI) has become increasingly used in the field of botany (Boughton and Thinagaran, 2018;Shimma and Sagawa, 2019;Hou et al, 2022;Ikuta et al, 2022). MSI provides a much finer spatial resolution compared to traditional analysis methods, such as LC-MS.…”

Mass Spectrometry Imaging: An Emerging Technology in Medical Parasitology

“…Importantly, the discovery of differential metabolites in tissues and the identification of their biological functions have emerged as a powerful and complementary approach to genomic, transcriptomic, and classical metabolomic studies. 9,10 Currently, MSI technology is progressively integrated into a wide range of studies, including clinical analysis, 11,12 cancer research, 13,14 microbiology, 15 molecular ecology, and drug discovery. 16 MSI has the unique capability of producing multiplex molecular information with exceptional specificity, all without the need for fluorescent or radioactive labels.…”

“…9,10 Currently, MSI technology is progressively integrated into a wide range of studies, including clinical analysis, 11,12 cancer research, 13,14 microbiology, 15 molecular ecology, and drug discovery. 16 MSI has the unique capability of producing multiplex molecular information with exceptional specificity, all without the need for fluorescent or radioactive labels. These technologies applied in medical parasitology mainly include matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) and desorption electrospray ionization mass spectrometry imaging (DESI-MSI).…”

“…It allows for the qualitative, semiquantitative, and in situ analysis of thousands of metabolites in biological tissues. , When combined with bioinformatics analysis, MSI not only complements traditional metabolomics and chemical analysis but also develops into a spatial metabolomics method, allowing for in situ analysis from biological tissues. Importantly, the discovery of differential metabolites in tissues and the identification of their biological functions have emerged as a powerful and complementary approach to genomic, transcriptomic, and classical metabolomic studies. , Currently, MSI technology is progressively integrated into a wide range of studies, including clinical analysis, , cancer research, , microbiology, molecular ecology, and drug discovery …”

APS celebrates the 90th anniversary of SIMM

“…This rapid clinical approval has greatly improved the competitiveness of new drug molecules on the market. The new drug molecules currently under clinical research involve various types of diseases such as tumors, metabolic diseases, infections, autoimmune, respiratory, mental, allergic, neurological, Hematologic, digestive, cardiovascular, and urinary diseases [1][2][3][4][5][6][7][8][9][10][11]. Researching these different types of disorders, SIMM has developed 13 new drugs and 1 generic drug that have been approved for clinical and international registration in the United States, Japan, Europe, and many other countries around the world.…”