2023
DOI: 10.1038/s41598-023-49440-3
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Mass spectrometry in cerebrospinal fluid uncovers association of glycolysis biomarkers with Alzheimer’s disease in a large clinical sample

Matthijs B. de Geus,
Shannon N. Leslie,
TuKiet Lam
et al.

Abstract: Alzheimer’s disease (AD) is a complex and heterogeneous neurodegenerative disorder with contributions from multiple pathophysiological pathways. One of the long-recognized and important features of AD is disrupted cerebral glucose metabolism, but the underlying molecular basis remains unclear. In this study, unbiased mass spectrometry was used to survey CSF from a large clinical cohort, comparing patients who are either cognitively unimpaired (CU; n = 68), suffering from mild-cognitive impairment or dementia f… Show more

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Cited by 7 publications
(2 citation statements)
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“…Recently, subpopulations of SST INs, including neuropeptide Y (NPY) SST-INs, have been implicated in cognitive resilience, with overrepresentation of this cell-type in human cortex linked to resilience against AD neuropathology 14 . Accordingly, cerebrospinal fluid from individuals with AD-dementia has lower levels of NPY than aged-matched controls 68 . Notably, NPY SST-INs also express other neuropeptide signalling molecules that we associated with cognitive resilience, including protachykinin-1 (TAC1) and VGF (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, subpopulations of SST INs, including neuropeptide Y (NPY) SST-INs, have been implicated in cognitive resilience, with overrepresentation of this cell-type in human cortex linked to resilience against AD neuropathology 14 . Accordingly, cerebrospinal fluid from individuals with AD-dementia has lower levels of NPY than aged-matched controls 68 . Notably, NPY SST-INs also express other neuropeptide signalling molecules that we associated with cognitive resilience, including protachykinin-1 (TAC1) and VGF (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Pyruvate upregulation has also been suggested as a therapeutic avenue for dementia [115] . However, research outcomes regarding pyruvate levels in individuals with AD have been mixed, with some studies reporting increases [110,116] while others indicating decreases [117,118] in CSF.…”
Section: Lactate and Pyruvatementioning
confidence: 99%