2007
DOI: 10.2174/187152107780361689
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Mass Spectrometry, Proteomics, Data Mining Strategies and Their Applications in Infectious Disease Research.

Abstract: The ultimate goal of proteome research is the comprehensive description of all proteins present in a given sample using qualitative, quantitative and functional metrics. Traditionally, protein mixtures were first separated by twodimensional gel electrophoresis and spots of interest were excised, in-gel digested and analyzed by mass spectrometry (MS). In most cases, protein identification was done by MALDI-TOF-MS (matrix-assisted laser desorption/ionization time-of-flight). The methodology is time consuming and… Show more

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Cited by 3 publications
(2 citation statements)
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References 139 publications
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“…6 Newly developed ionization techniques, such as MALDI and electrospray ionization, have expanded the capabilities well beyond that of standard trace gas analysis to polymers, 7 nanomaterials, 8 and biological molecules, detected either intact or through digestive techniques such as proteomics. 9 Continuing development of ionization techniques and mass spectrometric methodology promises to increase its applicability in nearly all aspects of scientific and forensic analysis.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…6 Newly developed ionization techniques, such as MALDI and electrospray ionization, have expanded the capabilities well beyond that of standard trace gas analysis to polymers, 7 nanomaterials, 8 and biological molecules, detected either intact or through digestive techniques such as proteomics. 9 Continuing development of ionization techniques and mass spectrometric methodology promises to increase its applicability in nearly all aspects of scientific and forensic analysis.…”
Section: Introductionmentioning
confidence: 99%
“…In addition to the analytical applications, mass spectrometry also plays an important role in many chemical studies, ranging from simple GC-MS analysis of a reaction mixture to being an integral detection technique for physical studies of gas-phase reactivity and structure . Newly developed ionization techniques, such as MALDI and electrospray ionization, have expanded the capabilities well beyond that of standard trace gas analysis to polymers, nanomaterials, and biological molecules, detected either intact or through digestive techniques such as proteomics . Continuing development of ionization techniques and mass spectrometric methodology promises to increase its applicability in nearly all aspects of scientific and forensic analysis.…”
Section: Introductionmentioning
confidence: 99%