Mass Transfer Coefficient: Comparison between Methods

Teixidó, J; Cofan, Frederic; Borràs, Mercè; Bonet, Josep M. Serra i; Bonal, Jordi; Galimany, R.; Biosca, C; Caralps, A

doi:10.1177/089686089301302s12

Cited by 9 publications

(12 citation statements)

References 6 publications

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“…The PET was used for evaluation of peritoneal transport for several reasons: First, the PET provides a simple quantitative assessment of peritoneal membrane function (18). Second, several authors have suggested that the 4-hour D/P ratio is a good measure of solute transfer, comparable with calculation of the mass transfer coefficient (20,21).…”

Section: Discussionmentioning

confidence: 77%

The Longitudinal Effect of a Single Peritonitis Episode on Peritoneal Membrane Transport in CAPD Patients

et al. 2000

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Objective To evaluate the longitudinal effect of a single peritonitis episode on peritoneal membrane transport. Design A prospective longitudinal study. Setting Department of nephrology in a university hospital. Patients Eighteen continuous ambulatory peritoneal dialysis patients with peritonitis. Methods Peritoneal transport for low, middle, and high molecular weight (MW) solutes was evaluated by peritoneal equilibration test (PET). The first PET was performed on the day following the diagnosis of peritonitis. The test was repeated at weeks 1, 2, 4, 12, and 24 and the results were compared to baseline PET data obtained before peritonitis. In addition, dialysate CA125 concentration and leukocyte count were measured. Results During peritonitis there were significant increases in dialysate-to-plasma (D/P) ratios for all low, middle, and high MW solutes except potassium, and decreases in D4/D0 glucose ratio and ultrafiltration (UF) volume. Over the subsequent 2 weeks, solute transport gradually decreased to the baseline values then remained unchanged during follow-up. Although net UF volume demonstrated a similar course during the study, it did not completely return to the baseline value. No decrease in D/P sodium ratio was found at 60 minutes during the PET performed 24 weeks after peritonitis. The percent change in solute transport during peritonitis compared to baseline value was significantly correlated with a solute's MW ( r = 0.776, p = 0.014). The slope of the regression line for D/P ratios versus MW, in double logarithmic scale, before peritonitis (-0.73 ± 0.09) was steeper than the slope during peritonitis (-0.59 ± 0.08). Conclusions These findings indicate that a single peritonitis episode does not permanently affect peritoneal solute transport. However, the loss of net UF that accompanies peritonitis is not completely recovered, probably due to impairment of transcellular water transport. The transport changes associated with peritonitis may be due to the combined effect of increased effective peritoneal surface area and intrinsic permeability. Our findings suggest that the latter mechanism seems to be more important.

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Section: Discussionmentioning

confidence: 77%

The Longitudinal Effect of a Single Peritonitis Episode on Peritoneal Membrane Transport in CAPD Patients

et al. 2000

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“…To characterize peritoneal small solute transport further, the mass transfer area coefficient (MTAC) for creatinine was calculated with the simplified Garred method, validated for clinical purposes [23][24][25]. Median MTAC creatinine was 9.3 ml/min [interquartile range (IQR) 6.6-13.1 ml/min].…”

Section: Methodsmentioning

confidence: 99%

Peritoneal fast transport in incident peritoneal dialysis patients is not consistently associated with systemic inflammation

Rodrigues¹,

Almeida²,

Fonseca³

et al. 2005

Nephrology Dialysis Transplantation

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“…Good correlations between MTAC calculations and PET were reported (27). Most patients have stable transport rates as judged by repeated equilibration tests and clinical observation.…”

Section: Peritoneal Equilibration Testmentioning

confidence: 74%

Creatinine Kinetics in Peritoneal Dialysis

Meyer

Venkataraman

Twardowski

1998

Seminars in Dialysis

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Creatinine has been used as a convenient tool to determine and follow various aspects of renal function. The aim of this article is to review creatinine kinetics in peritoneal dialysis and its clinical applications, such as monitoring dialysis adequacy and the nutritional status of a patient, control of adherence to an individual dialysis prescription, and modeling of dialysis prescriptions according to the individual needs of a patient. Creatinine MetabolismMost of the creatinine in the human body is produced from nonenzymatic hydrolysis of phosphocreatine. Since muscle is the main reservoir of creatine, total muscle mass and its metabolism account for the majority of creatinine production. The dietary intake of preformed creatinine, or its precursor creatine in meat-based diets, is an additional source. Creatinine is a relatively inert solute of low molecular weight (1 13 daltons) that is excreted unchanged in the urine. Extrarenal degradation in the gut occurs in patients with elevated serum creatinine levels (1).Endogenous creatinine production can be calculated by the formulas of Cockcroft and Gault (2) as modified by Mitch, Collier, and Walser (3): daily creatinine production in men (mg/kg) = 28 -(0.2 x age in years) 23.8 -(0.17 x age in years) daily creatinine production in women (mg/kg) = According to the formula of Mitch, Collier, and Walser (3), the amount of extrarenal degradation of creatinine (mg/day) can be calculated as: 0.38 x serum Cr (mg/dL) x body weight (kg) Creatinine is traditionally used as a marker for nonmeasurable low molecular weight toxins that accumulate in renal failure. High creatinine levels are implicated in uremic thrombopathy (4) and in decreased erythrocyte survival (5) but have otherwise not proven to be toxic in the uremic state (6).

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Mass Transfer Coefficient: Comparison between Methods

Cited by 9 publications

References 6 publications

The Longitudinal Effect of a Single Peritonitis Episode on Peritoneal Membrane Transport in CAPD Patients

The Longitudinal Effect of a Single Peritonitis Episode on Peritoneal Membrane Transport in CAPD Patients

Peritoneal fast transport in incident peritoneal dialysis patients is not consistently associated with systemic inflammation

Creatinine Kinetics in Peritoneal Dialysis

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