Mass Transfer Effects in Liquid Chromatography Simulation

Abstract

For analytical and some small preparative columns in LC, mass transfer resistance is usually negligible and the equilibrium theory suffices [1]. However, for preparative columns with smaller plate numbers and large-scale columns, mass transfer effects are often significant and usually cannot be neglected. The study of mass transfer effects for single-component systems has been carried out by many researchers [2]. For example, Lee et al. [3] studied the mass transfer effects in nonlinear multicomponent elution ion-exchange chromatography. They discussed the differences between a general rate model and the equilibrium theory under various mass transfer conditions.