Mass Transfer, Gas Holdup, and Kinetic Models of Batch and Continuous Fermentation in a Novel Rectangular Dynamic Membrane Airlift Bioreactor

Li, Ganlu; Chen, Kequan; Yan, Weizhen; Zeng, Jinlei; Yang, Yue; He, Feng; Li, Hui; Ouyang, Pingkai

doi:10.1016/j.eng.2021.07.025

Cited by 11 publications

(7 citation statements)

References 51 publications

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“…Unlike the logistic model which is purely based on some mechanistic fundamentals of biological population growth, the Monod model is rigidly empirical and intended to fit experimental data of cell growth rate vs. growth-limiting substrate concentration (Liu, 2007 ; Fuad, 2020 ). In this study, a hybrid logistic-Monod model (Equation 4) was employed to consider both substrate-limiting and self-inhibiting factors (Xu, 2020 ; Li et al, 2022 ; Tsafrakidou et al, 2022 ). In this hybrid model, fungal biomass accumulation and substrate degradation initially proceeded through the substrate-limiting stage indicated by the Monod equation and progressively shifted toward the self-inhibiting stage characterized by the logistic equation.…”

Section: Methodsmentioning

confidence: 99%

Modeling the microbial pretreatment of camelina straw and switchgrass by Trametes versicolor and Phanerochaete chrysosporium via solid-state fermentation process: A growth kinetic sub-model in the context of biomass-based biorefineries

et al. 2023

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Advancing microbial pretreatment of lignocellulose has the potential not only to reduce the carbon footprint and environmental impacts of the pretreatment processes from cradle-to-grave, but also increase biomass valorization, support agricultural growers, and boost the bioeconomy. Mathematical modeling of microbial pretreatment of lignocellulose provides insights into the metabolic activities of the microorganisms as responses to substrate and environment and provides baseline targets for the design, development, and optimization of solid-state-fermentation (SSF) bioreactors, including substrate concentrations, heat and mass transfer. In this study, the growth of Trametes versicolor 52J (TV52J), Trametes versicolor m4D (TVm4D), and Phanerochaete chrysosporium (PC) on camelina straw (CS) and switchgrass (SG) during an SSF process was examined. While TV52J illustrated the highest specific growth rate and maximum cell concentration, a mutant strain deficient in cellulose catabolism, TVm4D, performed best in terms of holocellulose preservation and delignification. The hybrid logistic-Monod equation along with holocellulose consumption and delignification models described well the growth kinetics. The oxygen uptake rate and carbon dioxide production rate were directly correlated to the fungal biomass concentration; however, a more sophisticated non-linear relationship might explain those correlations better than a linear model. This study provides an informative baseline for developing SSF systems to integrate fungal pretreatment into a large-scale, on-farm, wet-storage process for the utilization of agricultural residues as feedstocks for biofuel production.

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Section: Methodsmentioning

confidence: 99%

Modeling the microbial pretreatment of camelina straw and switchgrass by Trametes versicolor and Phanerochaete chrysosporium via solid-state fermentation process: A growth kinetic sub-model in the context of biomass-based biorefineries

et al. 2023

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“…Therefore, Li et effectively improve the gas−liquid specific surface area, and improve k L a. 15 Compared with the traditional stirred reactor, the dynamic membrane stirred reactor not only effectively solves the defects of uneven gas−liquid dispersion and high shear and easy coalescence of bubbles in the traditional reactor but also simplifies the reactor structure. 16 At present, there is little research on dynamic membrane reactors, so it is of great significance to improve mass transfer efficiency for its in-depth research.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, Li et al developed a new type of dynamic membrane impeller based on an ordinary impeller. The combination of a microporous membrane and impeller can effectively disperse microbubbles, effectively improve the gas–liquid specific surface area, and improve k L a . Compared with the traditional stirred reactor, the dynamic membrane stirred reactor not only effectively solves the defects of uneven gas–liquid dispersion and high shear and easy coalescence of bubbles in the traditional reactor but also simplifies the reactor structure .…”

Section: Introductionmentioning

confidence: 99%

Bubble Diameter, Mass Transfer, and Bioreaction of Dynamic Membrane-Stirred Reactors

Gan,

Liu,

Wei

et al. 2024

Ind. Eng. Chem. Res.

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The gas–liquid mass transfer of reactors is the focus of intensifying biochemical engineering. Hence, this paper develops a dynamic membrane-stirred reactor to increase the gas–liquid mass transfer efficiency (k L a) and improve bioreactions. Dynamic membrane coupling mixing and aeration form uniform microbubbles to intensify gas–liquid mass transfer. The optimal pore diameter and blade angle of the dynamic membrane are 10 μm and 45°, respectively, providing more uniform microbubbles, better gas–liquid mixing performance, higher gas holdup, and better k L a. Compared with the traditional stirred reactor, the dynamic membrane-stirred reactor reduces the energy consumption by 50% and improves biomass and enzyme activity. The maximum dry cell weight is 30.13 g·L–1, and the maximum specific cell growth rate is 0.38 h–1, 48.9% higher and 31% higher than the traditional reactor. To sum up, the unique structure of a dynamic membrane-stirred reactor effectively reduces the bubble diameter and improves k L a and the bioreaction process.

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“…Several parameters affect how the design will achieve its desired aims. For instance, the nature of the living microorganism, optimal operational conditions for growth and reproduction, as well as the nature of the function assigned to it [Li et al, 2022;Mu, et al, 2021;Abdulmajeed and Ibrahim, 2018; Al-Mashhadani, and Khudhair, 2017]. The bubbling-type bioreactors feature reduced control necessities and lower shear drives as compared to other mechanical internal components in conventional fermenters [Zhang, et al 2019;Yank, et al, 2018;FU, et al, 2003].…”

Section: Introductionmentioning

confidence: 99%

Verification of Dead Zones Generated in Bioreactors as a Proactive Stage in Bioreactor Design

Al-Mashhadani¹

2023

J. Ecol. Eng.

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The activity and growth of microorganisms for renewable energy production are still influenced by the dead zones created in bioreactors. These areas form a nutrient and thermal gradient, causing an abundance of food in certain areas compared to famines in other areas of same bioreactor. The current study is a step in identifying those dead zones, followed by another step in improving the flow of media inside the reactor. The results indicated that the inner parts of the bioreactor may be a crucial factor in the creation and spread of such dead zones. For example, the position of the disc-type diffuser contributes to the generation of those areas at the bottom of the reactor. It was inferred from the fluid movement in reactors using the annular-type diffuser proposed in the current study. The bubble size, gas mass flux, and radiuses of fillet, as the most important factors, were examined in both bioreactors. The results revealed a noticeable improvement in these parameters in this area of the reactor when the disc diffuser was replaced by the annular diffuser. For example, the average liquid velocity was recorded in the lower part of the modernized reactor at 0.0198 m/s, while the velocity was recorded in the conventional reactor at 0.00077 m/s under same bubbles diameter used in both reactors (0.125 mm). The inclusion of the effect of the presence of microorganisms in mathematical models was also addressed in the current study. The results showed that the amount of oxygen remaining at the bottom of the reactor after bio-consumption in the presence of the annular diffuser was higher than that in the conventional reactor. This clearly emphasizes the importance of the design of the internal parts of the bioreactor.

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Mass Transfer, Gas Holdup, and Kinetic Models of Batch and Continuous Fermentation in a Novel Rectangular Dynamic Membrane Airlift Bioreactor

Cited by 11 publications

References 51 publications

Modeling the microbial pretreatment of camelina straw and switchgrass by Trametes versicolor and Phanerochaete chrysosporium via solid-state fermentation process: A growth kinetic sub-model in the context of biomass-based biorefineries

Modeling the microbial pretreatment of camelina straw and switchgrass by Trametes versicolor and Phanerochaete chrysosporium via solid-state fermentation process: A growth kinetic sub-model in the context of biomass-based biorefineries

Bubble Diameter, Mass Transfer, and Bioreaction of Dynamic Membrane-Stirred Reactors

Verification of Dead Zones Generated in Bioreactors as a Proactive Stage in Bioreactor Design

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