Mass Transport Properties of Progesterone and Estradiol in Model Microemulsion Formulations

Abstract

In systems nearly saturated with drug, the microemulsion formulation leads to a greatly enhanced rate of steady-state mass transport while in systems with drug loading far from saturation, the microemulsion formulation appears to have a minimal ability to promote mass transport. The aqueous boundary layer diffusion model was successful in fitting progesterone results but was not successful for estradiol.

Formation of stable nanoemulsions by ultrasound-assisted two-step emulsification process for topical drug delivery: Effect of oil phase composition and surfactant concentration and loratadine as ripening inhibitor

“…Moreover, nanoemulsions with oleic acid showed high loading capacity (near saturation) compared with coconut oil nanoemulsions. This observation is consistent with the work done by Land et al(2006) who reported that systems with near saturation leads to a great enhancement in mass transport. This near saturation may undergo supersaturation from microemulsions during occluded application and forms an additional driving force with small nanoparticles as reported by Kemken et al (1992).…”

Chronocoulometry diffusion coefficients as a measure of cyclodextrin–estradiol complex association

“…This value is slightly higher than values previously reported in water [10][11][12]. But, the presence of ethanol in this media could provoke an increase in diffusion coefficient.…”

Study of the Interaction between Progesterone and β-Cyclodextrin by Electrochemical Techniques and Steered Molecular Dynamics

“…This value is similar to values previously reported by other techniques. 50 As the drug is incorporated into the cavity, its diffusion coefficient is reduced due to the larger complex formed. This decrease is due to the lower diffusion coefficient of the cyclodextrin complex compared with the free guests.…”