Massa ventricular e critérios eletrocardiográficos de hipertrofia: avaliação de um novo escore

Mazzaro, Cleber do Lago; Costa, Francisco de Assis; Bombig, Maria Teresa Nogueira; Filho, Bráulio Luna; Paola, Ângelo Amato Vincenzo de; Ac, Carvalho; Costa, Waldemar S.; Fonseca, Francisco Antônio Helfenstein; Póvoa, Rui

doi:10.1590/s0066-782x2008000400003

Cited by 12 publications

(8 citation statements)

References 20 publications

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“…This criterion, which uses the sum of the highest R wave and the highest S wave in the horizontal plane, multiplied by a higher duration of the QRS complex, has a consistent basis from the physical point of view, as the relation of increased electrical activity in LVH is shown by a spatial vector that has amplitude and duration. The higher expression of the R and S waves and the QRS complex represented by this vector showed good correlation with left ventricular mass 8 .…”

Section: Colosimo Et Al Ecg: Lvh Degree and Gendermentioning

confidence: 72%

“…The modified Devereux formula 15 has good correlation with the left ventricular mass in necropsy studies (r = 0.90; p < 0.001) and applies to normal geometry ventricles, considered to be ellipsoid and within standards that allow volume extrapolation by the cube formula. In spite of the undeniable contribution of the echocardiogram in the diagnosis and knowledge of LVH, its cost is much higher than that of the ECG, in addition to its methodological limitations regarding reproducibility, as it depends greatly on the observer, a fact that limits its use in epidemiological studies 8 .…”

Section: Discussionmentioning

confidence: 99%

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Sensibilidade do eletrocardiograma na hipertrofia ventricular de acordo com gênero e massa cardíaca

Colossimo¹,

Costa²,

Riera³

et al. 2011

Arq. Bras. Cardiol.

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Section: Colosimo Et Al Ecg: Lvh Degree and Gendermentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Sensibilidade do eletrocardiograma na hipertrofia ventricular de acordo com gênero e massa cardíaca

Colossimo¹,

Costa²,

Riera³

et al. 2011

Arq. Bras. Cardiol.

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“…The R-wave amplitude was moderately but not statistically increased in the hearts of the young male AS160 Thr649Ala knockin mice, and significantly increased in the hearts of the old male and young female AS160 Thr649Ala knockin mice under normal conditions. The increased R-wave amplitude is a diagnostic marker for cardiac hypertrophy [ 23 ]. Although the ratio of heart to body weight was increased in the AS160 Thr649Ala knockin mice, the hearts showed no hypertrophic symptom as evidenced by the heart weight (data not shown) and the left ventricle mass detected by Echo ( Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

PKB-Mediated Thr649 Phosphorylation of AS160/TBC1D4 Regulates the R-Wave Amplitude in the Heart

et al. 2015

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The Rab GTPase activating protein (RabGAP), AS160/TBC1D4, is an important substrate of protein kinase B (PKB), and regulates insulin-stimulated trafficking of glucose transporter 4. Besides, AS160/TBC1D4 has also been shown to regulate trafficking of many other membrane proteins including FA translocase/CD36 in cardiomyocytes. However, it is not clear whether it plays any role in regulating heart functions in vivo. Here, we found that PKB-mediated phosphorylation of Thr649 on AS160/TBC1D4 represented one of the major PAS-binding signals in the heart in response to insulin. Mutation of Thr649 to a non-phosphorylatable alanine increased the R-wave amplitude in the AS160Thr649Ala knockin mice. However, this knockin mutation did not affect the heart functions under both normal and infarct conditions. Interestingly, myocardial infarction induced the expression of a related RabGAP, TBC1D1, in the infarct zone as well as in the border zone. Together, these data show that the Thr649 phosphorylation of AS160/TBC1D4 plays an important role in the heart’s electrical conduction system through regulating the R-wave amplitude.

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“…Several ECG criteria were described for left ventricular hypertrophy , such as the classical voltage criteria, including the Sokolow-Lyon criteria: sum of the S wave in V1 and of the R wave in V5 or V6 ≥ 35 mm [ 74 ], and combined criteria, including the Cornell product [ 75 ], the Romhilt-Estes scoring system [ 76 ], and the Mazzaro score [ 77 ].…”

Section: Ecg Ventricular Hypertrophymentioning

confidence: 99%

Electrocardiographic Predictors of Cardiovascular Mortality

Mozoş

Caraba

2015

Disease Markers

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Cardiovascular diseases are the main causes of mortality. Sudden cardiac death may also appear in athletes, due to underlying congenital or inherited cardiac abnormalities. The electrocardiogram is used in clinical practice and clinical trials, as a valid, reliable, accessible, inexpensive method. The aim of the present paper was to review electrocardiographic (ECG) signs associated with cardiovascular mortality and the mechanisms underlying those associations, providing a brief description of the main studies in this area, and consider their implication for clinical practice in the general population and athletes. The main ECG parameters associated with cardiovascular mortality in the present paper are the P wave (duration, interatrial block, and deep terminal negativity of the P wave in V1), prolonged QT and Tpeak-Tend intervals, QRS duration and fragmentation, bundle branch block, ST segment depression and elevation, T waves (inverted, T wave axes), spatial angles between QRS and T vectors, premature ventricular contractions, and ECG hypertrophy criteria.

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Massa ventricular e critérios eletrocardiográficos de hipertrofia: avaliação de um novo escore

Abstract: SummaryBackground: The left ventricular hypertrophy (LVH) is an important and independent cardiovascular risk factor. There is a scarcity of studies in Brazil designed to test the efficacy of the electrocardiogram (ECG) in the diagnosis of this important pathological process.

Cited by 12 publications

References 20 publications

Sensibilidade do eletrocardiograma na hipertrofia ventricular de acordo com gênero e massa cardíaca

Sensibilidade do eletrocardiograma na hipertrofia ventricular de acordo com gênero e massa cardíaca

PKB-Mediated Thr649 Phosphorylation of AS160/TBC1D4 Regulates the R-Wave Amplitude in the Heart

Electrocardiographic Predictors of Cardiovascular Mortality

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