TALYS is a software package for the simulation of nuclear reactions below 200 MeV. It is used worldwide for the analysis and prediction of nuclear reactions and is based on state-of-art nuclear structure and nuclear reaction models. A general overview of the implemented physics and capabilities of TALYS is given. The general nuclear reaction mechanisms described are the optical model, direct reactions, compound nucleus model, pre-equilibrium reactions and fission. The most important nuclear structure models are those for masses, discrete levels, level densities, photon strength functions and fission barriers. A wide variety of nuclear reactions simulated with TALYS will be demonstrated, ranging from low-energy neutron cross sections, astrophysics, highenergy charged particle reactions and other reactions. TALYS is a nuclear reaction software which aims to give a complete description of nuclear reaction observables, and to be an important link between fundamental nuclear physics and applications.Eur. Phys. J. A (2023) 59:131• residual production (n, x) A Z El, mostly relevant at higher energies, as far as not yet covered by the exclusive channels mentioned above, • production of the ground state and isomers, if present, e.g. (n, n )A(g) Z El, (n, n )A(m) Z