Massive BACT chemotherapy with autologous bone marrow transplantation in 17 cases of non-Hodgkin's malignant lymphoma with a very bad prognosis

Philip, Thierry; Biron, Pierre; Hervé, P.; Dutou, L; Ehrsam, A.; Philip, I; Souillet, G; Plouvier, Emmanuel; Mevel, A. Le; Philippe, N; Vuvan, O.; Bouffet, Éric; Bachmann, Patrick; Cordier, J.-F.; Freyçon, F; Brunat‐Mentigny, M.

doi:10.1016/0277-5379(93)90006-q

Cited by 50 publications

(5 citation statements)

References 8 publications

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“…In a review of our own data (results not shown), we found that patients receiving bone marrow ASCT (BM-ASCT) between 1991 to 1994 had longer engraftment time, higher grade of acute toxicity, greater IP incidence, and greater transplant-related mortality (#33%). This finding is consistent with others, who have found BM-ASCT to be more toxic than PBSCT (18,19). Because of these significant problems with BM-ASCT, we restricted our study to patients who had received PBSCT.…”

Section: Discussionsupporting

confidence: 90%

Total Body Irradiation Compared With BEAM: Long-Term Outcomes of Peripheral Blood Autologous Stem Cell Transplantation for Non-Hodgkin's Lymphoma

Liu¹,

Seftel²,

Rubinger³

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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Section: Discussionsupporting

confidence: 90%

Total Body Irradiation Compared With BEAM: Long-Term Outcomes of Peripheral Blood Autologous Stem Cell Transplantation for Non-Hodgkin's Lymphoma

Liu¹,

Seftel²,

Rubinger³

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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“…Similar to most previously reported cases, our patient's left heart valves were involved . Graft versus host disease (GVHD) requiring at least 2 immunosuppressive medications was present in 4 out of the 6 cases …”

Section: Discussionsupporting

confidence: 85%

“…1,7,8,10,12,[14][15][16][17][18][19][20][21][22][23][24] Graft versus host disease (GVHD) requiring at least 2 immunosuppressive medications was present in 4 out of the 6 cases. 1,7,11,[25][26][27] Aspergillus endocarditis was reported in 23 patients post solid TA B L E 2 (Continued) regimen was reported in 4 out of the 23 cases. 10,13,17,28 CMV infection was reported in 2 cases.…”

Section: A S E His Torymentioning

confidence: 99%

Aspergillus flavus native valve endocarditis following combined liver and renal transplantation: Case report and review of the literature

Alsobayeg

Alshehri

Mohammed

et al. 2018

Transplant Infectious Dis

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“…Our inability (as that of others [26]) to demonstrate such grafts [24] and by Faille et a1 for allogeneic grafts [25]. no.…”

Section: Antitumor Effectmentioning

confidence: 86%

“…Both observed one long term survivor. More recently Hartmann et al [34] obtained remissions of 5+ to 16+ months in four of 11 children with relapsed Bcell NHL and Philip et a1 [26] reported on three of eight children with relapsed or resistant Burkitt's NHL surviv-ing disease-free for 102 + to 600 + days after aggressive cytoreductive therapy and ABMT.…”

Section: Onementioning

confidence: 99%

Autologous bone marrow transplantation in the treatment of children and adolescents with advanced malignant tumors

Baumgartner

Bleher

et al. 1984

Med. Pediatr. Oncol.

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Nineteen patients with advanced malignant tumors, less than 20 years old were treated with intensive chemotherapy (vincristine 2 mg/m2 i.v. and adriamycin 60 mg/m2 i.v. on day - 7; cyclophosphamide 45 mg/kg i.v. on days -6 to -3), total body irradiation (TBI, 600 rads on day -1) and autologous bone marrow transplantation (ABMT, day 0). Prior to this procedure induction of complete or partial remission by conventional therapy was attempted. Ten patients had intra-abdominal non-Hodgkin's lymphoma (NHL); three, yolk sac tumor; three, Ewing's sarcoma; and three, neuroblastoma. The supportive care included reverse isolation, immunoglobulin 400 mg/kg i.v. q 2 weeks, cotrimoxazole per os, and cell support as needed. No correlation between the bone marrow dose and the time of hematological reconstitution could be established. Five of seven patients with intra-abdominal NHL stage III (transplanted in first remission) are surviving disease-free for 5+, 5+, 20+, 23+, and 35+ months after ABMT. None of three patients with intra-abdominal NHL stage IV is surviving (two of them were transplanted in second remission). One of three patients with yolk sac tumor is surviving disease-free for 27+ months. There are no survivors among the patients with Ewing's sarcoma and neuroblastoma. Only one of 19 patients was lost due to therapeutic complications, while 12 died due to tumor. Regarding treatment results for advanced intra-abdominal NHL, the procedure described here is comparable to the best conventional regimens. In vitro methods for tumor cell eradication in the collected bone marrow might further improve the results of ABMT.

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Massive BACT chemotherapy with autologous bone marrow transplantation in 17 cases of non-Hodgkin's malignant lymphoma with a very bad prognosis

Cited by 50 publications

References 8 publications

Total Body Irradiation Compared With BEAM: Long-Term Outcomes of Peripheral Blood Autologous Stem Cell Transplantation for Non-Hodgkin's Lymphoma

Total Body Irradiation Compared With BEAM: Long-Term Outcomes of Peripheral Blood Autologous Stem Cell Transplantation for Non-Hodgkin's Lymphoma

Aspergillus flavus native valve endocarditis following combined liver and renal transplantation: Case report and review of the literature

Autologous bone marrow transplantation in the treatment of children and adolescents with advanced malignant tumors

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