Massive gastrointestinal haemorrhage associated with ileal lymphoid hyperplasia in Gaucher's disease

Jones, Daniel; Hoffman, James S.; Downie, R.; Haqqani, M T

doi:10.1136/pgmj.67.787.479

Cited by 10 publications

(6 citation statements)

References 16 publications

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“…On the other hand, NLH often presents with tinged or streaky rectal bleeding in neonates and infants. Massive GI bleeding secondary to NLH has been previously reported in both adolescent and adult patients [5,6].…”

Section: Discussionmentioning

confidence: 97%

Diffuse microscopic angiodysplasia and nodular lymphoid hyperplasia in an infant with obscure massive lower gastrointestinal bleeding: a diagnostic challenge

Choi

Park

Hwang

et al. 2009

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 97%

Diffuse microscopic angiodysplasia and nodular lymphoid hyperplasia in an infant with obscure massive lower gastrointestinal bleeding: a diagnostic challenge

Choi

Park

Hwang

et al. 2009

Journal of Pediatric Surgery

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“…Involvement of the digestive tract is uncommon. Hemorrhage associated with lymphoid hyperplasia of the ileum, bleeding esophageal varices secondary to liver disease, and the presence of a mesenteric mass inducing abdominal discomfort have been reported [78][79][80]. Accumulation of macrophages is unusual but has been described.…”

Section: Metabolic Disordersmentioning

confidence: 98%

Macrophage-related diseases of the gut: a pathologist's perspective

2012

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The resident macrophages of the gastrointestinal tract represent the largest population of macrophages in the human body and are usually located in the subepithelial lamina propria. This strategic location guarantees a first-line defense to the huge numbers of potentially harmful bacteria and antigenic stimuli that are present in the intestinal lumen. In non-inflamed mucosa, macrophages phagocytose and kill microbes in the absence of an inflammatory response. However, in the event of an epithelial breach and/or microbial invasion, new circulating monocytes and lymphocytes will be recruited to the damaged area of the gut, which will result in the secretion of proinflammatory mediators and engage a protective inflammatory response. Although macrophages are usually not conspicuous in normal mucosal samples of the gut, they can easily be detected when they accumulate exogenous particulate material or endogenous substances or when they become very numerous. These events will mostly occur in pathologic conditions, and this review presents an overview of the diseases which are either mediated by or affecting the resident macrophages of the gut.

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“…Hemorrhage of the stomach or intestine is uncommon; a few cases of gastrointestinal hemorrhage associated with gastric ulcer [12] or ileal lymphoid hyperplasia [13] have been reported.…”

Section: Discussionmentioning

confidence: 99%

A Case of Adult Type 1 Gaucher Disease Complicated by Temporal Intestinal Hemorrhage

Ito

Saito

Numakura

et al. 2013

Case Rep Gastroenterol

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A 21-year-old man with a history of sudden rectal hemorrhage was referred to our hospital. Examination disclosed thrombocytopenia and hepatosplenomegaly. A liver biopsy specimen demonstrated Gaucher cells in Glisson's capsule. Additional investigations revealed a low level of leukocyte β-glucosidase activity and common mutations of the glucocerebrosidase gene, L444P/D409H. We diagnosed the patient with Gaucher disease type 1. He underwent enzyme replacement therapy. Thrombocytopenia and hepatosplenomegaly improved at a rate of approximately 50 and 20%, respectively, within 6 months. This case suggests that we must pay attention to adult Gaucher disease as a differential diagnosis for cryptogenic thrombocytopenia.

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Massive gastrointestinal haemorrhage associated with ileal lymphoid hyperplasia in Gaucher's disease

Cited by 10 publications

References 16 publications

Diffuse microscopic angiodysplasia and nodular lymphoid hyperplasia in an infant with obscure massive lower gastrointestinal bleeding: a diagnostic challenge

Diffuse microscopic angiodysplasia and nodular lymphoid hyperplasia in an infant with obscure massive lower gastrointestinal bleeding: a diagnostic challenge

Macrophage-related diseases of the gut: a pathologist's perspective

A Case of Adult Type 1 Gaucher Disease Complicated by Temporal Intestinal Hemorrhage

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