Massive gliosis of the retina: report of a case investigated by immunohistochemistry and clonality assays

Retinal ependymoma: an immunohistologic and ultrastructural study

“…When sizable, such reactive astrocytic proliferation (massive retinal gliosis) can be difficult to differentiate from astrocytoma. Nonetheless, their overall bland, uniform cytologic appearance, devoid of pleomorphism, and foci of hypercellularity, point toward a reactive process, as does their lack of clonality [9].…”

Review on Retinal Gliosis Illustrated with a Series of Massive Glioses and Focal Nodular Gliosis Cases in Regard to Potential Pitfalls of Ocular Reactive Tumor-like Lesions of this Type

“…10,11 As a proof of non neoplastic nature, MRG was shown to be polyclonal in nature in analysis of tumor clonality using a human androgen receptor assay in case of a 32-year-old woman with bilateral microphthalmia. 22 The lesion classically was composed of spindle cells with delicate fi brillary cytoplasm and glial fi brillary acidic protein and neuron-specifi c enolase and partly S-100 protein positivity consistent with mainly non-atypical astrocytes with atrophic residues of retinal epithelium and sclera at the margins of the lesion. 22 The same pattern of staining for GFAP and S100 was revealed in our present report.…”

“…22 The lesion classically was composed of spindle cells with delicate fi brillary cytoplasm and glial fi brillary acidic protein and neuron-specifi c enolase and partly S-100 protein positivity consistent with mainly non-atypical astrocytes with atrophic residues of retinal epithelium and sclera at the margins of the lesion. 22 The same pattern of staining for GFAP and S100 was revealed in our present report. The lesion classically contains GFAP-positive spindled fi brous astrocytes with Alcian blue negativity of stroma as well as no aberration of TP53 gene and normal level of p16 expression.…”