Massive Hemoptysis in Cystic Fibrosis

Flume, Patrick A.; Yankaskas, James R.; Ebeling, Myla; Hulsey, Thomas C.; Clark, Leslie L.

doi:10.1378/chest.128.2.729

Cited by 195 publications

(145 citation statements)

References 29 publications

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“…Use of anti-inflammatory treatment in infectious patients can result in clinical recovery or improvement (14,15). Various studies have shown that inflammation and bacterial infection occur at an early age, before the manifestation of the main clinical symptoms.…”

Section: Discussionmentioning

confidence: 99%

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Microbial Colonization and Drug Resistance in Patients with Cystic Fibrosis

et al. 2012

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Section: Discussionmentioning

confidence: 99%

“…The results obtained by Flume et al for the clinical symptoms of CF (13) are in agreement with those presented here. Bronchiectasis causes focal hemorrhagic pneumonia, which can explain the occurrence of bloody sputum in CF patients (14). Chest CT scan findings show that 48% of patients develop bronchiectasis (15).…”

Section: Discussionmentioning

confidence: 99%

Microbial Colonization and Drug Resistance in Patients with Cystic Fibrosis

et al. 2012

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“…The only available data described an excess of angiogenesis in CF polyps and elevated levels of VEGF in the serum of cystic fibrosis patients [5,6]. Angiogenesis and vascular remodeling are key elements participating in tissue remodeling in various chronic airway inflammatory diseases such as asthma and chronic bronchitis [4,13].…”

Section: Discussionmentioning

confidence: 99%

“…Signs of excessive angiogenesis have been already reported in CF patients who develop highly vascularized nasal polyps requiring surgical resection. In addition, angiogenesis-related complications, such as pulmonary hemorrhage and hemoptysis commonly occur in CF patients [5]. In addition, a previous report has shown higher levels of vascular endothelial growth factor (VEGF) in the serum of CF patients than in other pulmonary inflammatory disorders.…”

mentioning

confidence: 99%

Intrinsic pro-angiogenic status of cystic fibrosis airway epithelial cells

Verhaeghe

Tabruyn

Oury

2007

Biochemical and Biophysical Research Communications

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Cystic fibrosis is a common genetic disorder characterized by a severe lung inflammation and fibrosis leading to the patient's death. Enhanced angiogenesis in cystic fibrosis (CF) tissue has been suggested, probably caused by the process of inflammation, as similarly described in asthma and chronic bronchitis. The present study demonstrates an intrinsic pro-angiogenic status of cystic fibrosis airway epithelial cells. Microarray experiments showed that CF airway epithelial cells expressed several angiogenic factors such as VEGF-A, VEGF-C, bFGF, and PLGF at higher levels than control cells. These data were confirmed by real-time quantitative PCR and, at the protein level, by ELISA. Conditioned media of these cystic fibrosis cells were able to induce proliferation, migration and sprouting of cultured primary endothelial cells. This report describes for the first time that cystic fibrosis epithelial cells have an intrinsic angiogenic activity. Since excess of angiogenesis is correlated with more severe pulmonary disease, our results could lead to the development of new therapeutic applications.

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“…Approximately 4.1% of all patients with CF will suffer massive, potentially fatal haemoptysis during their lifetime and the average annual incidence is 0.87% [22].…”

Section: Complicationsmentioning

confidence: 99%

Adult cystic fibrosis care in the 21st century

Garattini

Bilton

Cremona

et al. 2015

Monaldi Arch Chest Dis

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Cystic fibrosis (CF) is the most common autosomal recessive inherited disease of Caucasian populations. As a result of a variety of diagnostic and therapeutic strategies there has been a dramatic increase in the life expectancy of patients with CF in the last decades and 50% of patients are now adults. This review will focus on the disease in adults and the provision of appropriate care. The complex care required to improve the survival and quality of life in the adult patients can best be provided in a dedicated adult cystic fibrosis unit. These units currently exist in many European countries, but more are needed in Italy.

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Massive Hemoptysis in Cystic Fibrosis

Cited by 195 publications

References 29 publications

Microbial Colonization and Drug Resistance in Patients with Cystic Fibrosis

Microbial Colonization and Drug Resistance in Patients with Cystic Fibrosis

Intrinsic pro-angiogenic status of cystic fibrosis airway epithelial cells

Adult cystic fibrosis care in the 21st century

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