Massive Hepatic Necrosis in a Patient Receiving Allopurinol

Butler, Robert C.

doi:10.1001/jama.1977.03270320051024

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1977

2003

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Cited by 26 publications

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“…This is the reason why allopurinol is often administered to patients with renal disease. However, allopurinol (AL) may cause severe side‐effects including liver dysfunction, Stevens–Johnson syndrome and suppression of bone marrow function (7, 8). It has been suggested that these adverse effects may be due to hypersensitivity to AL and its metabolite oxypurinol (OX) (9), as well as an accumulation of OX in the body (10).…”

Section: Introductionmentioning

confidence: 99%

Facile and rapid high-performance liquid chromatography method for simultaneous determination of allopurinol and oxypurinol in human serum

Tada

Fujisaki

Itoh

et al. 2003

Journal of Clinical Pharmacy and Therapeutics

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Section: Introductionmentioning

confidence: 99%

Facile and rapid high-performance liquid chromatography method for simultaneous determination of allopurinol and oxypurinol in human serum

Tada

Fujisaki

Itoh

et al. 2003

Journal of Clinical Pharmacy and Therapeutics

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Allopurinol hepatotoxicity

Chawla

Patel

Parrino

et al. 1977

Arthritis & Rheumatism

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The allopurinol hypersensitivity syndrome. Unnecessary morbidity and mortality

Singer

Wallace

1986

Arthritis & Rheumatism

213

108

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Patients receiving allopurinol are at risk of developing the allopurinol hypersensitivity syndrome, an immunologic reaction to the drug, characterized by multiple abnormalities such as fever, rash, decreased renal function, hepatocellular injury, leukocytosis, and eosinophilia. The records of 8 patients with the allopurinol hypersensitivity syndrome evaluated at the Downstate Medical Center hospitals and an additional 72 patients described in the literature were reviewed. All were seriously ill. Three of the 8 patients at the Downstate Medical Center hospitals died as a result of allopurinol hypersensitivity; 19 of the 72 previously described patients also died from consequences of taking the drug. Only 1 of our 8 patients with allopurinol hypersensitivity was given allopurinol for an appropriate reason. Eight of the 59 previously described patients on whom there was adequate information had legitimate indications for allopurinol therapy. Severe, often fatal iatrogenic disease occurred unnecessarily in the others.

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Massive Hepatic Necrosis in a Patient Receiving Allopurinol

Cited by 26 publications

References 3 publications

Facile and rapid high-performance liquid chromatography method for simultaneous determination of allopurinol and oxypurinol in human serum

Facile and rapid high-performance liquid chromatography method for simultaneous determination of allopurinol and oxypurinol in human serum

Allopurinol hepatotoxicity

The allopurinol hypersensitivity syndrome. Unnecessary morbidity and mortality

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