Massive intracardiac metastases secondary to squamous cell carcinoma located at the level of the penis

Portero, Jaime Nevado; Pardo, F. López; Pérez, Roberto Fornell

doi:10.1016/j.ijcard.2007.04.092

Cited by 4 publications

(4 citation statements)

References 1 publication

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“…The third case showed a massive metastatic neoplastic infiltration of the heart, at the level of the interatrial and interventricular septa, the free wall of both ventricles, the perivalvular mitral area, the pericardium, and the ventricular apex. In this case, the diagnosis was made before the patient’s death and was also confirmed during autopsy 24. The same search on Science Direct resulted in a single article reviewing the atypical sites of metastatic penile cancer.…”

Section: Discussionmentioning

confidence: 82%

Intracardiac metastasis of squamous cell carcinoma of the penis

Siqueira¹,

Tomikawa²

2013

ACR

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Penile cancer shows variable incidence in different countries with a higher prevalence in developing countries. Squamous cell carcinoma represents the most common histologic type. The seventh decade of life corresponds to the mean age at diagnosis, but it is not an unusual diagnosis among young adults. Most cases present as “in situ” neoplasia or loco regional disease; however, systemic disseminated disease occurs via lymphatic and/or hematogeneous routes. The lymph nodes, liver, and lungs are the most frequently involved sites whereas the heart constitutes an exceptional and atypical site for penile cancer metastases. We report a case of a 79-year-old patient who presented a metastatic squamous cell carcinoma of the penis with intracardiac dissemination. The patient had a past history of cardiomyopathy, which required an artificial cardiac pacemaker implantation. He had been treated 1 year before with a partial penectomy but was admitted for emasculation due to the cancer relapse. During the postoperative period, he experienced sudden respiratory distress and died. The autopsy findings showed metastatic disease into the cardiac right chambers, pulmonary tumoral thrombi, and pulmonary hilar involvement. The authors call attention to the possibility of the presence of pacing leads, cardiomyopathy and the altered low blood flow in the right chambers, as predisposing factors for the tumoral seeding in this case.

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Section: Discussionmentioning

confidence: 82%

Intracardiac metastasis of squamous cell carcinoma of the penis

Siqueira¹,

Tomikawa²

2013

ACR

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“…This malignancy may mimic as a primary osteosarcoma of tibia [4] or as hypercalcemia and pathological fracture of the humerus [5]. Orbital [6], heart [7], and adrenal [8] metastasis are also reported in literature.…”

Section: Discussionmentioning

confidence: 99%

Pathological Fracture of the Femur by Metastatic Carcinoma Penis—a Rare Presentation

et al. 2015

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We report herein a clinical case of a patient with femur fracture due to metastasis from penile squamous cell carcinoma. A young man, who was treated for carcinoma penis, presented with pathological fracture of femur and lung metastasis from metastatic carcinoma penis after 18 months. Long bone metastasis from penile cancer is extremely rare, to the best of our knowledge; this is the first report of a patient with penile cancer spread to the femur from primary squamous cell carcinoma of the penis.

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“…16 The frequent presence of cardiac involvement is noteworthy; we found 3 previous reports of cardiac metastases from a penile cancer. [17][18][19] The not unusual presence of arrhythmias in patients with penile cancer under chemotherapy treatment (A. Yagoda, personal communication), and the fact that in one of the reported cases 18 a fatal arrhythmia was the proposed cause of death, would indicate that this particular finding is probably related to the presence of the cardiac metastasis itself; the presence of arrhythmias in patients with high-risk penile cancer should alert clinicians about the possibility of heart involvement. Another unusual finding was the presence of hypercalcemia, detected in one of our patients.…”

Section: Discussionmentioning

confidence: 99%

Autopsy Findings in 14 Patients With Penile Squamous Cell Carcinoma

et al. 2009

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The aim of this study was to describe pathologic features found at autopsy of 14 patients with penile cancer. Nine patients died from disseminated disease; 5 of them presented local/regional recurrences. Five patients died from other causes, 2 of them postoperatively. Local recurrence sites were corpus cavernosum, Buck's fascia and urethra, regional skin, and prostate. Metastatic sites were lymph nodes (9 cases), liver (7 cases), lungs (6 cases), heart (5 cases), adrenals, bone and skin (3 cases each), thyroid and brain (2 cases each), and pancreas, spleen, and pleura (1 case each). Patients with heart metastasis had arrhythmias. Patients who died and who did not die from penile cancer had different profiles: low-grade superficial tumors with usual and warty subtypes versus high-grade deeply invasive basaloid or hybrid verrucous/sarcomatoid carcinomas. A natural history model for penile cancer routes of spread is proposed: local intrapeneal, regional and systemic nodes, regional skin, liver, lungs, heart, and other multiple sites.

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Massive intracardiac metastases secondary to squamous cell carcinoma located at the level of the penis

Cited by 4 publications

References 1 publication

Intracardiac metastasis of squamous cell carcinoma of the penis

Intracardiac metastasis of squamous cell carcinoma of the penis

Pathological Fracture of the Femur by Metastatic Carcinoma Penis—a Rare Presentation

Autopsy Findings in 14 Patients With Penile Squamous Cell Carcinoma

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