Massive upper gastrointestinal bleeding after organophosphate poisoning: a case report

Gupta, Sourabh; Kumar, Rakesh; Agrawal, Archana; Aggarwal, Bindu; Gupta, Sanjay

doi:10.1177/0049475517741775

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…GI symptoms that present in OP poisoning cases mostly include diarrhea, stomach cramps, and increased salivation [6]. Nevertheless, GI bleeding has also been reported in several cases [4,5,8]. This can be in the form of upper GI bleeding, delayed colonic bleeding, or multiple small intestinal perforations.…”

Section: Discussionmentioning

confidence: 99%

“…An old paper which summarizes nine patients with circumferential intestinal ulcers has also mentioned that the cause of this type of ulcer was idiopathic [13]. In some articles, OP-induced internal bleeding has been reported [4,5,8]. In two reports, OPs caused GI bleeding, and bowel perforation was considered to have resulted in microvascular thrombosis, which led to bowel wall ischemia.…”

Section: Discussionmentioning

confidence: 99%

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A case report of delayed lower intestinal bleeding after organophosphate poisoning

2021

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Background Organophosphate poisoning is a serious issue and it results in significant casualties in developing countries. Since agriculture remains an important and necessary sector of human society and organophosphate are commonly used in agriculture, it is difficult to prevent organophosphate poisoning. Gastrointestinal bleeding is not a common but life threatening symptom of organophosphate poisoning. We report a rare case of gastrointestine bleeding due to organophosphate poisoning. Case presentation A 78-year-old woman presented to our hospital approximately 12 h after ingesting a mouthful of organophosphate and benzodiazepines in a suicide attempt. Six weeks after successful medical treatment for respiratory failure, she developed recurring melena. Colonoscopy and esophagogastroduodenoscopy findings were negative for ulcers or bleeding. Enteroscopy revealed severe circumferential ulcers with luminal narrowing 10 cm proximal to the ileocecal valve. The patient underwent a 100-cm ileum resection after failed medical treatment and recovered uneventfully. The resected terminal ileum demonstrated severe inflammation and a sharp transitional zone between the healthy and injured mucosa approximately 50 cm proximal to the ileocecal valve. Pathological examination revealed an injured mucosa with inflammatory cell infiltration and structural damage. This case highlights a rare event of OP poisoning with late-onset lower gastrointestinal bleeding, which prolonged the patient’s recovery course and parenteral alimentation period. Conclusion We report a rare case of a patient with organophosphate poisoning, with late-onset lower GI tract bleeding, which raised clinical awareness regarding the organophosphate poisoning that induce intestinal symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A case report of delayed lower intestinal bleeding after organophosphate poisoning

2021

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Case Report: Upper gastrointestinal bleeding and multiorgan injury caused by ethylicin poisoning

Hu,

Li,

et al. 2024

Front. Pharmacol.

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Ethylicin is a pesticide with excellent bactericidal ability. The incidence of poisoning has increased in recent years with the widespread use of ethylicin in green agriculture, but reports are lacking. In this study, we described three cases of oral ethylicin poisoning. Patients developed severe upper gastrointestinal bleeding after oral administration of ethylicin. Gastroscopy showed extensive mucosal erosions and ulcerations in the esophagus, stomach, and duodenum. Impaired consciousness, multiorgan injury, irreversible shock, and cardiac arrest were observed in cases where larger doses of ethylicin were ingested. Patients were treated with comprehensive therapeutic measures, including total gastrointestinal decontamination, medications such as proton pump inhibitors and somatostatin to reduce gastric bleeding. Endoscopic hemostasis was performed when pharmacologic hemostasis was not effective. Parenteral nutritional support and organ function support were given. In patients’ follow up, esophageal stenosis and dysphagia during feeding was noted, which severely affected the quality of life. Ethylicin poisoning has been a public health problem and the awareness should be raised.

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Massive upper gastrointestinal bleeding after organophosphate poisoning: a case report

Cited by 2 publications

References 3 publications

A case report of delayed lower intestinal bleeding after organophosphate poisoning

A case report of delayed lower intestinal bleeding after organophosphate poisoning

Case Report: Upper gastrointestinal bleeding and multiorgan injury caused by ethylicin poisoning

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