Mast Cell–Biomaterial Interactions and Tissue Repair

Ozpinar, Emily W; Frey, Ariana L; Cruse, Glenn; Freytes, Donald O.

doi:10.1089/ten.teb.2020.0275

Cited by 29 publications

(18 citation statements)

References 98 publications

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“…Most studies have mainly quantified just shifts in mast cell numbers associated with biomaterial implantation, the results of which are suspect given the general low numbers of mast cells in tissue. [78] The reader is directed to an excellent review by Ozpinar et al, [79] on the influence of various biomedical implant design factors (i.e., natural versus synthetic material of construction, topography/porosity, biologically activated or decorated) on MC responses.…”

Section: Mast Cellsmentioning

confidence: 99%

Biocompatibility Evolves: Phenomenology to Toxicology to Regeneration

Crawford

Wyatt

Bryers

et al. 2021

Adv Healthcare Materials

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The word "biocompatibility," is inconsistent with the observations of healing for so-called biocompatible biomaterials. The vast majority of the millions of medical implants in humans today, presumably "biocompatible," are walled off by a dense, avascular, crosslinked collagen capsule, hardly suggestive of life or compatibility. In contrast, one is now seeing examples of implant biomaterials that lead to a vascularized reconstruction of localized tissue, a biological reaction different from traditional biocompatible materials that generate a foreign body capsule. Both the encapsulated biomaterials and the reconstructive biomaterials qualify as "biocompatible" by present day measurements of biocompatibility. Yet, this new generation of materials would seem to heal "compatibly" with the living organism, where older biomaterials are isolated from the living organism by the dense capsule. This review/perspective article will explore this biocompatibility etymological conundrum by reviewing the history of the concepts around biocompatibility, today's standard methods for assessing biocompatibility, a contemporary view of the foreign body reaction and finally, a compendium of new biomaterials that heal without the foreign body capsule. A new definition of biocompatibility is offered here to address advances in biomaterials design leading to biomaterials that heal into the body in a facile manner.

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Section: Mast Cellsmentioning

confidence: 99%

Biocompatibility Evolves: Phenomenology to Toxicology to Regeneration

Crawford

Wyatt

Bryers

et al. 2021

Adv Healthcare Materials

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“…Once activated, MCs rapidly respond to signals from the surrounding microenvironment and attendant pathological conditions via migrating to an injury site and further mediating tissue damage and/or repair through releasing the granule into surroundings ( El Ansari et al, 2020 ). On the one hand, the activated MCs could facilitate wound healing by recognizing antigens through pattern recognition receptors and the high-affinity immunoglobulin E receptor, resulting in the releasing of granules, which further mediates cell recruitment, fibrosis, angiogenesis, and extracellular matrix deposition ( Ozpinar et al, 2020 ). One the other hand, the cytoplasmic granules from MCs also contribute to multiple inflammatory and allergic pathogenesis diseases, including asthma, allergy, arthritis, interstitial cystitis, irritable bowel syndrome (IBD), ulcers, and prostatitis ( Chelombitko et al, 2020 ; Fu et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Mast Cells Mediate Inflammatory Injury and Aggravate Neurological Impairment in Experimental Subarachnoid Hemorrhage Through Microglial PAR-2 Pathway

Qin

Peng

Chen

et al. 2021

Front. Cell. Neurosci.

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Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease with high mortality and disability. Aberrant neuroinflammation has been identified as a critical factor accounting for the poor prognosis of SAH patients. Mast cells (MCs), the sentinel cells of the immune system, play a critical in the early immune reactions and participate in multiple pathophysiological process. However, the exact role of MCs on the pathophysiological process after SAH has not been fully understood. The current study was conducted to determine the role of MCs and MC stabilization in the context of SAH. Mouse SAH model was established by endovascular perforation process. Mice received saline or cromolyn (MC stabilizer) or compound 48/80 (MCs degranulator). Post-SAH evaluation included neurobehavioral test, western blot, immunofluorescence, and toluidine blue staining. We demonstrated that SAH induced MCs activation/degranulation. Administration of MC stabilizer cromolyn conferred a better neurologic outcome and decreased brain edema when compared with SAH+vehicle group. Furthermore, cromolyn significantly inhibited neuroinflammatory response and alleviated neuronal damage after SAH. However, pharmacological activation of MCs with compound 48/80 dramatically aggravated SAH-induced brain injury and exacerbated neurologic outcomes. Notably, pharmacological inhibition of microglial PAR-2 significantly reversed MCs-induced inflammatory response and neurological impairment. Additionally, the effect of MCs-derived tryptase in mediating neuroinflammation was also abolished by the microglial PAR-2 blockage in vitro. Taken together, MCs yielded inflammatory injury through activating microglia-related neuroinflammation after SAH. These data shed light on the notion that MCs might be a novel and promising therapeutic target for SAH.

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Section: Definitions Methods and Implications Of Materials Porositymentioning

confidence: 99%

“…[122] The presence of pores and walls also implies the presence of texture or roughness at the material surface, which additionally impacts cell attachment, protein absorption, inflammatory responses, platelet activation, and bacterial adhesion. [25,37,[125][126][127][128] Increased porosity also decreases scaffold support which can inversely affect the mechanical integrity of the material. [36] While attachment, drug release, material erosion, and mechanical properties are impacted relatively by porosity, the specific selection of the material will also have a critical impact on these attributes.…”

Section: Implications Of Porosity On Biomaterials Propertiesmentioning

confidence: 99%

Medical Applications of Porous Biomaterials: Features of Porosity and Tissue‐Specific Implications for Biocompatibility

Hernandez

Woodrow

2022

Adv Healthcare Materials

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Porosity is an important material feature commonly employed in implants and tissue scaffolds. The presence of material voids permits the infiltration of cells, mechanical compliance, and outward diffusion of pharmaceutical agents. Various studies have confirmed that porosity indeed promotes favorable tissue responses, including minimal fibrous encapsulation during the foreign body reaction (FBR). However, increased biofilm formation and calcification is also described to arise due to biomaterial porosity. Additionally, the relevance of host responses like the FBR, infection, calcification, and thrombosis are dependent on tissue location and specific tissue microenvironment. In this review, the features of porous materials and the implications of porosity in the context of medical devices is discussed. Common methods to create porous materials are also discussed, as well as the parameters that are used to tune pore features. Responses toward porous biomaterials are also reviewed, including the various stages of the FBR, hemocompatibility, biofilm formation, and calcification. Finally, these host responses are considered in tissue specific locations including the subcutis, bone, cardiovascular system, brain, eye, and female reproductive tract. The effects of porosity across the various tissues of the body is highlighted and the need to consider the tissue context when engineering biomaterials is emphasized.

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Mast Cell–Biomaterial Interactions and Tissue Repair

Cited by 29 publications

References 98 publications

Biocompatibility Evolves: Phenomenology to Toxicology to Regeneration

Biocompatibility Evolves: Phenomenology to Toxicology to Regeneration

Mast Cells Mediate Inflammatory Injury and Aggravate Neurological Impairment in Experimental Subarachnoid Hemorrhage Through Microglial PAR-2 Pathway

Medical Applications of Porous Biomaterials: Features of Porosity and Tissue‐Specific Implications for Biocompatibility

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