Mast Cell Degranulation is Essential for Anastomotic Healing in Well Perfused and Poorly Perfused Rat Colon

Development of Mast Cells and Importance of Their Tryptase and Chymase Serine Proteases in Inflammation and Wound Healing

“…Coneely and coworkers evaluated MC degranulation in rats that had undergone surgical colon anastomosis (Coneely, Kennelly, Bouchier-Hayes, & Winter, 2010). These investigators found that intraperitoneal administration of compound 48/80 led to an increase in bursting pressure and hydroxyproline content of the hypoperfused bowel area, as well as stronger anastomosis.…”

Evidence That Mast Cells Are Not Required for Healing of Splinted Cutaneous Excisional Wounds in Mice

“…Mast cells also have been proposed to have a role in several aspects of host responses to tumors [6], [7], [8]. In addition, there has been considerable speculation that mast cells can play important roles in wound healing, particularly in the early phases, when inflammation and angiogenesis allow clearance of debris and the delivery of nutrients to the wound bed [7], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]. For example, it has been suggested that mast cell activation, resulting in degranulation and release of histamine and the synthesis and secretion of prostaglandin D 2 , can both promote repair [9], [15] and contribute to the formation of normal and pathological scarring [14], [19].…”

“…In addition, there has been considerable speculation that mast cells can play important roles in wound healing, particularly in the early phases, when inflammation and angiogenesis allow clearance of debris and the delivery of nutrients to the wound bed [7], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]. For example, it has been suggested that mast cell activation, resulting in degranulation and release of histamine and the synthesis and secretion of prostaglandin D 2 , can both promote repair [9], [15] and contribute to the formation of normal and pathological scarring [14], [19]. Indeed, mast cells can produce many growth factors with the potential to contribute to wound healing through effects on blood vessels [7], [20], [21], [22], as well as other products that can have complex effects on fibroblast proliferation and function [14], [17], [23], [24], [25].…”

GM6001 Increases Anastomotic Leakage following Colonic Obstruction Possibly by Impeding Epithelialization

“…There were few macrophages, lymphocytes, and plasma cells in either group. Mast cells were not observed in the granulation tissue, although they were occasionally present within the loose connective tissue of the adjacent uninjured colon [25]. Moreover, the amount of type I collagen appeared to be similar in the two groups ( Fig.…”