Mast Cell Heterogeneity: Effect of Anti-Allergic Compounds on Neuropeptide-Induced Histamine Release

Shanahan, Fergus; Lee, T. D. G.; Bienenstock, John; Befus, A D

doi:10.1159/000234092

Cited by 66 publications

(72 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, ingested enterotoxins penetrate the gut lining and trigger local and systemic immune responses which releases the inflammatory mediators such as histamine, leukotrienes, and neuroenteric peptide substance resulting in vomiting [18][19][20][21]. Activation of local immune system is also responsible for damage of gastrointestinal tract [13].…”

Section: Resultsmentioning

confidence: 99%

Rapid and sensitive method for detection of Staphylococcus aureus enterotoxin genes in milk sample

2018

J App Biol Biotech

View full text Add to dashboard Cite

Staphylococcus aureus is a common microflora present on skin and mucous membrane of cattle. Despite its amiable nature, S. aureus can turn shrewd and get to be distinctly pathogenic. Staphylococcus present in the milk may produce numerous potential destructive variables, like toxins. Consequently, consumption of S. aureus contaminant milk may result in Staphylococcal food poisoning (SFP). Therefore, the present study was carried out to evaluate the presence of Se-encoding genes in S. aureus and also validate the detection of toxin genes directly from the milk sample contaminated with S. aureus using real-time polymerase chain reaction (RT-PCR). The RT-PCR results were reported as Ct values, which confirmed the presence of enterotoxin genes in the S. aureus isolates and milk samples. Application of RT-PCR for the detection of Se genes in cultures of S. aureus and also from milk samples revealed the probable onset of SFP. Therefore, the study suggests that the analysis of milk for the presence of any toxin genes should be strictly performed before reaching the consumer.

show abstract

Section: Resultsmentioning

confidence: 99%

Rapid and sensitive method for detection of Staphylococcus aureus enterotoxin genes in milk sample

2018

J App Biol Biotech

View full text Add to dashboard Cite

show abstract

“…Probably dietary factors produced in the CNS itself, alone or in combination with hormone(s) which triggers the mast cells to the release of potent mediators such as histamineinducing oedemas-and neutral proteases-dissolving myelin [29]. Neurotensine, substance P, ATP and catestatin may stimulate mast cells in experimental animal in vitro systems [30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Mast cells and multiple sclerosis in females and males

Krüger¹,

Mörk²

2012

WJNS

View full text Add to dashboard Cite

Mast cells were observed in autopsies from 11 females and 8 males. We confirm earlier observations that mast cells are more frequent in close vicinity to MSplaques. In these plaque-border zone areas, defined as the area within 1 mm distance of the actual plaques, the average number of mast cells was 2.34/mm 2 in males and 4.77/mm 2 in females, which in average is appr. 10 times more than earlier observed in MS. The difference in number of mast cells between females and males is significant (p < 0.005) and is of interest since females are more inclined to developing MS than males. Mast cells were rare in areas without visible plaques. The mast cells were preferably located close to capillaries and venules. A mechanism for the probable role of mast cells, based on diet-factors and mast cell mediators in the pathogenesis of MS is discussed.

show abstract

“…For instance, mast cells from skin seem to be very sensitive to stimulation with substance P, compound 48/80 and morphine, all leading to histamine release, whereas heart and lung mast cells only react to compound 48/80 (Fureder et al, 1995). By contrast, intestinal mast cells do not react to compound 48/80 whereas uterine mast cells fail to respond to substance P (Shanahan et al, 1985).…”

mentioning

confidence: 87%

The fundamental contribution of William Bate Hardy to shape the concept of mast cell heterogeneity

Crivellato

Ribatti

2010

Br J Haematol

View full text Add to dashboard Cite

SummaryThis review article acknowledges the pioneering contribution of William Bate Hardy in shaping the concept of mast cell heterogeneity. In two outstanding papers, published in 1894 and 1895, he focussed on the ‘wandering cells’ (the modern leucocytes) in different mammalian species and distinguished two types of granular basophil cells, i.e., the coarsely granular basophil cells and the splanchnic basophil cells. These corresponded to the populations of connective tissue‐type and mucosal mast cells, respectively, described 70 years later by Enerbäck in rodents. Among the coarsely granular basophil cells, he also differentiated those cells which populated the serosal cavities – the so‐called coelomic coarsely granular basophil cells – from the common coarsely granular basophil cells, which were localized in the connective tissues. He stated that the granular basophil cells presented with different morphological and histochemical characteristics in diverse animal species as well as at different anatomical sites. Remarkably, he performed a series of functional experiments on the basophil cells as well as the other wandering cells, and suggested the view that different granular basophil cells might express functional specializations.

show abstract

Mast Cell Heterogeneity: Effect of Anti-Allergic Compounds on Neuropeptide-Induced Histamine Release

Cited by 66 publications

References 10 publications

Rapid and sensitive method for detection of Staphylococcus aureus enterotoxin genes in milk sample

Rapid and sensitive method for detection of Staphylococcus aureus enterotoxin genes in milk sample

Mast cells and multiple sclerosis in females and males

The fundamental contribution of William Bate Hardy to shape the concept of mast cell heterogeneity

Contact Info

Product

Resources

About