Mast cell modulation of the vascular and lymphatic endothelium

Kunder, Christian A.; John, Ashley L. St.; Abraham, Soman N.

doi:10.1182/blood-2011-07-358432

Cited by 173 publications

(172 citation statements)

References 129 publications

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“…These cells are able to facilitate the exit of leukocytes from postcapillary venules by rapid degranulation and the release of proinflammatory mediators [40]. Mast cells are not affected by the microsurgical preparation and do not contribute to the low baseline levels of preparationinduced leukocyte recruitment as we and others have reported previously [35,41].…”

Section: Mast Cell Inhibition Abolishes Cpg Tube-evoked Leukocyte Adhmentioning

confidence: 78%

DNA nanotubes as intracellular delivery vehicles in vivo

Sellner¹,

Kocabey²,

Nekolla³

et al. 2015

Biomaterials

103

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Section: Mast Cell Inhibition Abolishes Cpg Tube-evoked Leukocyte Adhmentioning

confidence: 78%

DNA nanotubes as intracellular delivery vehicles in vivo

Sellner¹,

Kocabey²,

Nekolla³

et al. 2015

Biomaterials

103

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“…It has been shown that heparin matrix protects mast cell mediators from degradation and influences tryptase and chymase bioactivities 8,13 . Moreover, Abraham and co-workers showed that the exocyted granules can serve as nanoparticles for progressive delivery of serglycin proteoglycansembedded compounds such as TNF 11,12 . Conversely, an early study, based on biochemical approaches, reported that chymase and heparin are retained on the rat mast cell surface upon degranulation 10 .…”

Section: Discussionmentioning

confidence: 99%

“…During the degranulation process, granule membranes fuse with each other and with the plasma membrane leading to the release of granule content into the surrounding environment. Some mediators, such as histamine, serotonin or b-hexosaminidase, quickly diffuse from the released granules, whereas others, such as tryptase, chymase or tumour-necrosis factor (TNF), dissociate more slowly allowing granule remnants to keep their biological activity for a prolonged time 8,[10][11][12] . Granule enzymes play numerous roles in immune responses 13,14 .…”

mentioning

confidence: 99%

Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence

et al. 2015

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Mast cells are tissue-resident immune cells that play a key role in inflammation and allergy. Here we show that interaction of mast cells with antibody-targeted cells induces the polarized exocytosis of their granules resulting in a sustained exposure of effector enzymes, such as tryptase and chymase, at the cell-cell contact site. This previously unidentified mast cell effector mechanism, which we name the antibody-dependent degranulatory synapse (ADDS), is triggered by both IgE-and IgG-targeted cells. ADDSs take place within an area of cortical actin cytoskeleton clearance in the absence of microtubule organizing centre and Golgi apparatus repositioning towards the stimulating cell. Remarkably, IgG-mediated degranulatory synapses also occur upon contact with opsonized Toxoplasma gondii tachyzoites resulting in tryptase-dependent parasite death. Our results broaden current views of mast cell degranulation by revealing that human mast cells form degranulatory synapses with antibody-targeted cells and pathogens for dedicated secretion and defence.

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“…(4) Which are the main mechanisms regarding mast cells' action on lymphatic endothelial cells? (5) Are mast cells able to induce lymphangiogenesis far from the site of inflammation or malignant process as it was suggested by two studies performed by Kunder et al (2009Kunder et al ( , 2011?…”

Section: Eosinophils and Mast Cellsmentioning

confidence: 99%

Lymphangiogenesis and Inflammation—Looking for the “Missing Pieces” of the Puzzle

Cimpean

Raica

2015

Arch. Immunol. Ther. Exp.

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Several papers about lymphangiogenesis and inflammation focused on the detailed and complicated descriptions of the molecular pathways accompanying both non-tumor and tumor inflammatory-induced lymphatic vessel development. Many authors are tempted to present inflammatory-induced lymphangiogenesis in pathologic conditions neglecting the role of inflammatory cells during embryonic lymphatic vessel development. Some of the inflammatory cells are largely characterized in inflammatory-induced lymphangiogenesis, while others as mast cells, eosinophils, or plasma cells are less studied. No phenotypic characterization of inflammation-activated lymphatic endothelial cell is available in this moment. Another paradox is related to the existence of few papers regarding lymphangiogenesis inside lymphoid organs and for their related pathology. There are still several "missing pieces of such a big puzzle" of lymphangiogenesis and inflammation, with a direct impact on the ineffectiveness of the anti-inflammatory therapy as lymphangiogenesis inhibitors. The present paper will focus on the controversial issues of lymphangiogenesis and inflammation.

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Mast cell modulation of the vascular and lymphatic endothelium

Cited by 173 publications

References 129 publications

DNA nanotubes as intracellular delivery vehicles in vivo

DNA nanotubes as intracellular delivery vehicles in vivo

Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence

Lymphangiogenesis and Inflammation—Looking for the “Missing Pieces” of the Puzzle

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