Mast cells and Kurloff cells - Their detection throughout the oestrous cycle in normal guinea pig ovaries and in guinea pigs with cystic rete ovarii

Hamouzová, Pavla; Jekl, Vladimír; Goździewska‐Harłajczuk, Karolina; Klećkowska‐Nawrot, Joanna

doi:10.1016/j.rvsc.2021.04.003

Cited by 4 publications

(4 citation statements)

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“…Mast cells seem to reach their highest level during the receptive phase (estrous) [ 37 ]. It was reported that histamine is released by MCs at the highest level immediately before the implantation phases [ 18 , 21 ]. Due to its role in tissue remodeling, MC-derived histamine and matrix metalloproteinase are thought to have a beneficial effect on implantation [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…The impact of ovarian hormones on the spatial distribution of MCs in reproductive organs has been investigated in many species [ 44 ]. The number and activity of MCs are positively correlated with estrogen concentrations in uterine tissue of sows and rats [ 18 , 50 ] and cervical tissue of mares [ 30 ]. The activation of MCs and the subsequent induction of their degranulation could be related to the high levels of locally produced estrogen (E2) [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Morphological and functional properties of MCs differ according to their location within the organism [3]. Mast cells are reported to be widely distributed throughout female reproductive organs, including the uterus, oviduct, and ovaries of mice, rats, hamsters, cows, and guinea pigs [5,[16][17][18]. Previous investigation under a light microscope has revealed changes in the characteristics and location of MCs in uterine and ovarian tissues.…”

Section: Introductionmentioning

confidence: 99%

“…It was noticed in cows (which demonstrate well-developed interstitial cortical stroma and a long estrous cycle) that MCs occupy the cortical and medullar tissue of the ovary [ 12 , 19 ]. Other studies have highlighted that MCs exist only in the medulla in rats and guinea pigs (which have short estrous cycles) [ 17 , 18 ]. Moreover, MCs were found in small numbers in the stromal tissue of the human endometrium [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

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The relationship between ovarian hormones and mast cell distribution in the ovaries of dromedary camel (Camelus dromedaries) during the follicular wave

et al. 2023

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Background and Aim: Mast cells (MCs) play an essential role in regulating tissue homeostasis through various non-allergic immune reactions. This study aimed to describe the salient features of MCs during different phases of the estrous cycle and evaluate the relationship between ovarian hormones and the presence of MCs in camel ovaries. Materials and Methods: Genital tracts (n = 28) of healthy, non-pregnant camels were collected from a local slaughterhouse. The follicular wave stage was determined according to structures on the ovaries using an ultrasound device. Stages were classified as "growing" (n = 12, FØ = 0.3–0.8 cm), "mature" (n = 9, FØ = 0.9–2.2 cm), or "regression" phase (n = 7, FØ >2.5). Blood samples were collected at slaughter to determine serum estradiol-17β and progesterone levels using an immunoassay. Safranin-O, periodic acid/Schiff, alcian blue, or methylene blue stains were used to detect MCs. Results: Follicular numbers at the growing, mature, and regression phases were determined to be 36, 14, and 7 follicles, respectively. Mast cells were widely but sparsely distributed within the ovarian tissue (9.3 MCs in the growing phase, 10.7 in the mature phase, and 7.0 in the regression phase). Typical histological features of MCs were observed in ovarian stromal tissue. Some MCs were found in the interstitial tissue, either near the follicular wall or the interstitial gland. Mast cells were present at a higher density during the mature phase than in the growing and regression phases in the ovarian matrix. A significantly reduced presence of MCs was found in the regression phase than in both the growing and mature phases (p < 0.05). A very strong positive correlation was observed between serum estradiol-17β concentrations and MC density in the ovaries (r = 0.9; p < 0.001). In addition, a strong negative correlation (r = –0.65; p = 0.03) was observed between the presence of MCs and serum progesterone concentrations. Conclusion: These findings suggest that the follicular wave phase and the associated hormonal concentration induce changes in the number of MCs in the camel ovary.

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