Mast cells and oral pathologies: A Review

Kamal, Reet; Dahiya, Parveen; Goyal, Niti; Kumar, Mukesh; Sharma, Neeta; Saini, Hans Raj

doi:10.4103/0976-9668.149075

Cited by 15 publications

(9 citation statements)

References 25 publications

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“…It is known that innate immune recognition of cells undergoing apoptosis, as a direct result of infection, is a physiological stimulus for Th17 cell differentiation. 56 Mast cells, also thought to play a role in pathogenesis, 15,27,50,62 are found in higher numbers in the deeper stromal tissue (as found in our dog study population) and often co-localize with IL-17þ cells.…”

Section: Discussionmentioning

confidence: 89%

“…Mast cells were generally located in areas away from (deep to) the intense lichenoid/ interface inflammation, and their role in CCUS lesion pathogenesis is therefore unclear. 15,27,50 Eosinophils were essentially absent from the examined tissue sections; therefore, an allergic response appears to be unlikely. The finding of IL-17-producing non-T cells in tissue sections is consistent with prior reports of chronic idiopathic inflammatory lesions in dogs, where most of the IL-17þ cells were CD3 negative.…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis

et al. 2017

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Canine chronic ulcerative stomatitis, also known as chronic ulcerative paradental stomatitis, is a painful condition of the oral cavity. The purpose of this study was to determine if there are commonalities in clinical and radiographic features among patients, whether the histopathologic evaluation might inform the pathogenesis, and whether the condition appears similar to human oral mucosal diseases. To do this, we prospectively collected clinical, radiographic, and histopathologic data from 20 dogs diagnosed with the disease. Clinical data were based on a clinical disease activity index, oral and periodontal examination parameters, and full-mouth dental radiographs. The histopathological and immunohistochemical data were based on oral mucosal samples obtained from erosive or ulcerated areas. Our findings revealed that canine chronic stomatitis is clinically characterized by painful oral mucosal ulcers of varying size, pattern, appearance, and distribution, most often associated with teeth with early periodontitis. Histologic examination revealed a subepithelial lichenoid band (interface mucositis) where B cells, T cells, and Forkheadbox protein 3 (FoxP3)-and interleukin-17-expressing cells were present. These cells might play a role in the underlying immune response and an immune-mediated pathogenesis is suspected. The clinical and histopathologic features of this chronic inflammatory mucosal disease in dogs resemble those of oral lichen planus in humans.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis

et al. 2017

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“…39 Future avenues of oral mucosal treatment can be expanded to mast cells and their role as effector cells of the immune system, for example. 146 Mature mast cells can help stimulate angiogenesis through increased vascular permeability during the inflammatory phase and can upregulate collagen synthesis to promote reepithelialization. [147][148][149] Similarly, therapies being developed for dental pulp regeneration and its immunoregulation of various immune cell subsets can also be explored as potential therapeutic agents for oral wound healing.…”

Section: Discussionmentioning

confidence: 99%

Oral wound healing models and emerging regenerative therapies

Toma

Fuller

Willett

et al. 2021

Translational Research

118

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Following injury, the oral mucosa undergoes complex sequences of biological healing processes to restore homeostasis. While general similarities exist, there are marked differences in the genomics and kinetics of wound healing between the oral cavity and cutaneous epithelium. The lack of successful therapy for oral mucosal wounds has influenced clinicians to explore alternative treatments and potential autotherapies to enhance intraoral healing. The present in-depth review discusses current gold standards for oral mucosal wound healing and compares endogenous factors that dictate the quality of tissue remodeling. We conducted a review of the literature on in vivo oral wound healing models and emerging regenerative therapies published during the past twenty years. Studies were evaluated by injury models, therapy interventions, and outcome measures. The success of therapeutic approaches was assessed, and research outcomes were compared based on current hallmarks of oral wound healing. By leveraging therapeutic advancements, particularly within in cell-based biomaterials and immunoregulation, there is great potential for translational therapy in oral tissue regeneration.

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“…Mast cells (MCs), also called mastocytes and labrocytes, are large connective tissue cells, distributed preferentially in the capillaries and containing many granules rich in histamine and heparin [ 154 ]. The granules in their cytoplasm are basophilic and may obscure the nucleus [ 154 ]. In the microenvironment of oral premalignant lesions, MCs are aberrantly increased and present different phenotypes.…”

Section: Introductionmentioning

confidence: 99%

Microenvironmental regulation of the progression of oral potentially malignant disorders towards malignancy

Yan

Hao

et al. 2017

Oncotarget

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Oral potentially malignant disorders (OPMD) develop in a complex tissue microenvironment where they grow sustainably, acquiring oral squamous cell carcinoma (OSCC) characteristics. The malignant tumor depends on interactions with the surrounding microenvironment to achieve loco-regional invasion and distant metastases. Unlike abnormal cells, the multiple cell types in the tissue microenvironment are relatively stable at the genomic level and, thus, become therapeutic targets with lower risk of resistance, decreasing the risk of OPMD acquiring cancer characteristics and carcinoma recurrence. However, deciding how to disrupt the OPMD and OSCC microenvironments is itself a daunting challenge, since their microenvironments present opposite capacities, resulting in diverse consequences. Furthermore, recent studies revealed that tumor-associated immune cells also participate in the process of differentiation from OPMD to OSCC, suggesting that reeducating stromal cells may be a new strategy to prevent OPMD from acquiring OSCC characteristics and to treat OSCC. In this review, we discuss the characteristics of the microenvironment of OPMD and OSCC as well as new therapeutic strategies.

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Mast cells and oral pathologies: A Review

Cited by 15 publications

References 25 publications

Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis

Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis

Oral wound healing models and emerging regenerative therapies

Microenvironmental regulation of the progression of oral potentially malignant disorders towards malignancy

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