Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1

Huygen, Frank; Ramdhani, Navin; Toorenenbergen, Albert van; Klein, Jan; Zijlstra, Freek J.

doi:10.1016/j.imlet.2003.11.013

Cited by 108 publications

(123 citation statements)

References 55 publications

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“…Inhibiting mast cell function with compound 48 / 80 sodium cromoglycate significantly suppresses the development of heathyperalgesia and mechano-allodynia in CCI rats and also reduces the recruitment of immune cells to the site of nerve injury (30,31). Cutaneous mast cells have been implicated in the pathogenesis of cutaneous hypersensitivity in patients with Complex Regional Pain Syndrome Type-1 (Reflex Sympathetic Dystrophy) (32). Moreover, activated mast cells in proximity to colonic nerves have been detected in patients with irritable bowel syndrome (33).…”

Section: Discussionmentioning

confidence: 99%

Systemic Glucocorticoid Therapy Reduces Pain and the Number of Endoneurial Tumor Necrosis Factor-Alpha (TNFα)-Positive Mast Cells in Rats With a Painful Peripheral Neuropathy

et al. 2008

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Abstract. Clinical and experimental evidence suggests that glucocorticoids may be effective in the treatment of neuropathic pain, but their mechanism of action is unknown. We gave triamcinolone (3 mg / kg) to rats with an experimental post-traumatic painful peripheral neuropathy, chronic constriction injury (CCI), five days after nerve injury, when the abnormal pain syndrome is known to be present; and pain sensitivity was measured on postoperative days 7 -14, a period during which symptoms are known to be at approximately peak severity. Additional CCI rats were treated similarly; and then they were sacrificed five days after the injection for an immunocytochemical analysis of endoneurial tumor necrosis factor-alpha (TNFα), macrophages, and mast cells in the sciatic nerve proximal to the site of injury. Vehicle-injected CCI rats demonstrated the expected neuropathic pain symptoms. Triamcinolone-treated CCI rats had a statistically significant reduction in the magnitude of heat-hyperalgesia and mechano-allodynia, but there was no effect on cold-allodynia or mechano-hyperalgesia. On the nerve-injured side of vehicle-injected rats, TNFα was present in Schwann cells and mast cells. On the nerve-injured side of triamcinolone-treated rats, there was a significant (71.5%) reduction in the number of TNFα-positive mast cells. Our results suggest that glucocorticoid therapy for neuropathic pain may work via the reduced expression of TNFα in endoneurial mast cells.

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Section: Discussionmentioning

confidence: 99%

Systemic Glucocorticoid Therapy Reduces Pain and the Number of Endoneurial Tumor Necrosis Factor-Alpha (TNFα)-Positive Mast Cells in Rats With a Painful Peripheral Neuropathy

et al. 2008

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“…Induced suction blisters from these individuals were collected, pooled, and used for our experiments. Blisters were induced by means of a suction method [18,19]. A seven-hole (5 mm diameter per hole) skin suction chamber was positioned on the ventral side of the skin of the forearm.…”

Section: Suction Blister Fluid Collectionmentioning

confidence: 99%

Suction blister fluid as potential body fluid for biomarker proteins

et al. 2007

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Early diagnosis is important for effective disease management. Measurement of biomarkers present at the local level of the skin could be advantageous in facilitating the diagnostic process. The analysis of the proteome of suction blister fluid, representative for the interstitial fluid of the skin, is therefore a desirable first step in the search for potential biomarkers involved in biological pathways of particular diseases. Here, we describe a global analysis of the suction blister fluid proteome as potential body fluid for biomarker proteins. The suction blister fluid proteome was compared with a serum proteome analyzed using identical protocols. By using stringent criteria allowing less than 1% false positive identifications, we were able to detect, using identical experimental conditions and amount of starting material, 401 proteins in suction blister fluid and 240 proteins in serum. As a major result of our analysis we construct a prejudiced list of 34 proteins, relatively highly and uniquely detected in suction blister fluid as compared to serum, with established and putative characteristics as biomarkers. We conclude that suction blister fluid might potentially serve as a good alternative biomarker body fluid for diseases that involve the skin.

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“…Several studies have demonstrated that suction-induced skin blisters on the affected but not the contralateral extremity of CRPS patients contain elevated levels of cytokines IL-6 and TNFα (Huygen et al 2002;Huygen et al 2004b). In addition, the cerebrospinal fluid (CSF) of CRPS patients contains increased levels of IL-1β and IL-6.…”

Section: Introductionmentioning

confidence: 99%

Pentoxifylline attenuates nociceptive sensitization and cytokine expression in a tibia fracture rat model of complex regional pain syndrome

Wei

Sabsovich

Guo

et al. 2009

European Journal of Pain

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Background-Tibia fracture in rats evokes chronic hindpaw warmth, edema, allodynia, and regional osteopenia, a syndrome resembling complex regional pain syndrome (CRPS). Previous studies suggest that the pathogenesis of some of these changes involves an exaggerated regional inflammatory response to injury and we postulated that inflammatory cytokines contribute to the development of CRPS-like changes after fracture.

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Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1

Cited by 108 publications

References 55 publications

Systemic Glucocorticoid Therapy Reduces Pain and the Number of Endoneurial Tumor Necrosis Factor-Alpha (TNFα)-Positive Mast Cells in Rats With a Painful Peripheral Neuropathy

Systemic Glucocorticoid Therapy Reduces Pain and the Number of Endoneurial Tumor Necrosis Factor-Alpha (TNFα)-Positive Mast Cells in Rats With a Painful Peripheral Neuropathy

Suction blister fluid as potential body fluid for biomarker proteins

Pentoxifylline attenuates nociceptive sensitization and cytokine expression in a tibia fracture rat model of complex regional pain syndrome

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