Mast cells/eosinophilic granule cells of teleostean fish: a review focusing on staining properties and functional responses

Reite, Ola B.

doi:10.1006/fsim.1998.0162

Cited by 125 publications

(134 citation statements)

References 96 publications

(162 reference statements)

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“…This might be related to the fact that the granulocytes are located in other tissues, such as dermis, intestinal tissue, gills, natatory bladder, hematopoietic tissue, nasal epithelium, heart and inflamed tissue in general (Ellis et al 1981, Suzuki and Iida 1992, Olabuenaga 2000, Valenzuela et al 2003. The granulocytes of thick grain belongs to an heterogeneous group of cells named mastocytes which plays a defensive role and are located in different tissues in the organism (Reite 1998).…”

Section: Discussionmentioning

confidence: 99%

Blood cytology of the common jollytail (Galaxias maculatus) (Jenyns, 1842) (Osmeriformes: Galaxiidae) at postlarval and adult stages

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Blood cytology of the common jollytail (Galaxias maculatus) (Jenyns, 1842) (Osmeriformes: Galaxiidae) at postlarval and adult stages

et al. 2011

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“…Regarding mast cells, their nature is still a matter of debate (Reite, 2005;Reite & Evensen, 2006). These cells are part of the host's inflammatory response and occur in site of parasite infection (Ferguson, 1989;Reite, 1998Reite, , 2005. Intestinal helminths of vertebrates can induce inflammation of the host digestive tract, resulting in altered gastrointestinal function, namely enhanced secretion and propulsive motility of the gut (Palmer & Greenwood-Van Meerveld, 2001).…”

Section: Discussionmentioning

confidence: 99%

The inflammatory response of fish to helminth parasites

Dezfuli¹,

Lui²,

Boldrini

et al. 2008

Parasite

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Summary :Fish serve as a good model for studying vertebrate immune systems because they have a relatively simple system. Descriptions of histopathological effects of helminth parasites on fish are few and far between with limited observations made on the identification of the inflammatory cells involved in the host reaction. Recently, two cell types found within teleosts received a great deal of attention, namely mast cells and rodlet cells. Fish mast cells also known as eosinophilic granule cells, are morphologically and functionally similar to their mammalian counterparts. Acute tissue damage causes mast cells degranulation and the release of mediators of inflammation, whereas, an increase in the number of these cells is usually found in chronically inflamed tissues. Rodlet cells, however, are exclusive to fish and are characterized by a distinct cell cortex and conspicuous inclusions, called rodlets, which accounts for their name. Piscidin has also been encountered within rodlet cells. As important cell types within the immune system of fish, both mast cells and rodlet cells have been seen to increase in number in infected fish, notably at the sites of pathogen attachment or infection. The present survey will provide data from studies with the light microscope on the response of mast cells and rodlet cells in a range of fish species (Anguilla anguilla, Oncorhynchus mykiss, Salmo trutta, Coregonus lavaretus) infected with a range of different parasite genera including representatives from the Digenea, Cestoda, Nematoda and Acanthocephala. frino et al., 1999; Dezfuli et al., 2000a Dezfuli et al., , 2002a Dezfuli et al., , b, 2003b Bosi et al., 2005). The cellular involvement in the inflammatory response in teleostean fish could be biphasic, initiating with an influx of neutrophils followed by latter arrival of monocytes/macrophages (Reite & Evensen, 2006). In fish, two inflammatory cell types, namely mast cells and rodlet cells (RCs) are closely linked to other piscine inflammatory cells (Reite, 1997; Dezfuli et al., 2000b). Mast cells are found mainly in the connective tissue distributed throughput the body, and are more frequently found in tegumentary, urinary, respiratory, reproductive and gastrointestinal systems (Rocha & Chiarini-Garcia, 2007). These cells have been noticed in all vertebrates, fish (Roberts et al., 1971;Reite, 1996), amphibians (Chiu & Lagunoff, 1972), reptiles (Sottovia-Filho & Taga, 1973), birds (Selye, 1965) and mammals (Galli, 1990; Chiarini-Garcia & Pereira, 1999). Nevertheless, there is some controversy in the literature about mast cells existence in fish despite the fact that early reviews of the mast cells left little doubt that this cell type was present in all groups of vertebrates (Reite & Evensen, 2006). In fish parasitized with helminths, greater number of mast cells was noticed in site of infection (Reite, 1997; Dezfuli et al., 2000b;Reite & Evensen, 2006). Regarding rodlet cells (RCs), they are characterized by a thick fibrous capsule, a basal nucleus, and conspicuous in...

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“…These cells are part of the host's inflammatory response and have been reported from the sites of parasite infection (Ferguson 1989, Reite 1998. They have also been encountered in the liver, pancreas and peritoneal serosa of minnows Phoxinus phoxinus (L.), infected with the larvae of the nematode Raphidascaris acus Bloch, 1779 (Dezfuli et al 2000).…”

Section: Resultsmentioning

confidence: 99%

Histopathology, ultrastructure and immunohistochemistry of Coregonus lavaretus hearts naturally infected with Ichthyocotylurus erraticus (Trematoda)

Dezfuli¹,

Giari²,

Simoni³

et al. 2005

Dis. Aquat. Org.

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Histopathological, ultrastructural and immunohistochemical investigations were conducted on 26 specimens of powan Coregonus lavaretus (L.) from Loch Lomond (Scotland). The hearts of all 26 powan (15 females and 11 males) investigated harboured metacercariae of the digenean trematode Ichthyocotylurus erraticus (Rudolphi, 1809). The vast majority of metacercariae were located either singly or as an aggregation of white cysts on the surface of the bulbus arteriosus. The intensity of infection ranged from 2 to 200 larvae heart -1 , although the number of metacercariae found on male powan did not exceed 13. Histochemically, the parasite cyst wall gave a strong positive reaction with periodic acid schiff (PAS) and a faint positive signal with Azan-Mallory stain. All the metacercariae cysts were embedded in a granulomatous proliferation of heart epicardium tissue, forming a reactive fibroconnective capsule around the parasite. The capsule enclosing the parasite (produced by the host's reaction to the parasite) measured 13.57 to 90.20 µm (37.43 ± 3.56) in thickness. Within the capsule wall, eosinophilic granular cells (EGCs), granulocytes, melanocytes and, in some instances, partially degenerated or vacuolated epithelioid cells were observed in close proximity to the cyst wall. Pigment-bearing macrophages were scattered throughout the granulomatous host-tissue reaction and as macrophage aggregates (MAs) within the capsules surrounding parasites. Immunohistochemical tests were applied to infected heart sections using 12 different antisera. Nerve fibres immunoreactive to bombesin, substance P (SP), and atrial natriuretic peptide (ANP) antisera were observed in close proximity to the parasite larvae. The presence of a serotonin-like substance was also observed within host immune-cells surrounding trematode cysts. Large cells of the epicardium were found to be immunoreactive to met-enkephalin and vasoactive intestinal peptide (VIP) antisera but not immunoreactive to anti-protein gene-product 9.5 (PGP9.5) sera. KEY WORDS: Trematode infection · Immunohistochemistry · Neuromodulators · Heart · Coregonus lavaretusResale or republication not permitted without written consent of the publisher

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Mast cells/eosinophilic granule cells of teleostean fish: a review focusing on staining properties and functional responses

Cited by 125 publications

References 96 publications

Blood cytology of the common jollytail (Galaxias maculatus) (Jenyns, 1842) (Osmeriformes: Galaxiidae) at postlarval and adult stages

Blood cytology of the common jollytail (Galaxias maculatus) (Jenyns, 1842) (Osmeriformes: Galaxiidae) at postlarval and adult stages

The inflammatory response of fish to helminth parasites

Histopathology, ultrastructure and immunohistochemistry of Coregonus lavaretus hearts naturally infected with Ichthyocotylurus erraticus (Trematoda)

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