Mast cells in breast cancer angiogenesis

Cîmpean, Anca Maria; Tamma, Roberto; Ruggieri, Simona; Nico, Beatrice; Toma, Alina

doi:10.1016/j.critrevonc.2017.04.009

Cited by 65 publications

(43 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Based on the high variety of mediators stored in the granules, the effects of MCs are versatile. As MCs can infiltrate the surrounding stroma of certain tumors, [69][70][71] many studies performed in human and mice focused on the role of MCs in tumor immunology. Whereas some studies revealed no effect of MCs on tumor progression, [72][73][74] others reported a positive role of MCs and pointed out MCs as responsible for tumor growth inhibition in mice, or related the presence of MCs to a good prognosis for the patient.…”

Section: Que S Ti Onab Le Role Of Ma S T Cell S In Tumor Immunologymentioning

confidence: 99%

Mast cells—Good guys with a bad image?

Meyer

Zenclussen

2018

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

Section: Que S Ti Onab Le Role Of Ma S T Cell S In Tumor Immunologymentioning

confidence: 99%

Mast cells—Good guys with a bad image?

Meyer

Zenclussen

2018

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

“…It has been shown that MC tryptase increases cell migration and invasion and promotes breast cancer invasion (6). MCs also take part in the inflammatory reaction occurring at the periphery of the tumor (12). Mast cell-secreted angiogenic cytokines facilitate tumor vascularization not only directly but also by stimulating other inflammatory cells of the tumor microenvironment to release other angiogenic mediators (12).…”

mentioning

confidence: 99%

Mast Cells as an Indicator and Prognostic Marker in Molecular Subtypes of Breast Cancer

Carpenco

Ceauşu

Cîmpean

et al. 2019

In Vivo

Self Cite

View full text Add to dashboard Cite

Background/Aim: Mast cells (MCs) represent the most controversial non-malignant element of the tumor microenvironment. Our aim was to study how MCs density and distribution (intratumoral-MCit versus peritumoral-MCpt) relate to tumor grade and molecular subtypes. Materials and Methods: MCs tryptase immunohistochemistry was performed on 80 cases of breast carcinomas. Results: For Luminal A tumors, a partial correlation was detected between MCit and progesterone receptor (PR) (p=0.005). Luminal B tumors showed a significant correlation between MCpt and age (p=0.009), estrogen receptor (ER) (p=0.017) and PR (p=0.035). MCit and MCpt were strongly interrelated in this subtype (p=0.002) and in triplenegative breast cancers (p=0.002). In HER2 subtype, MCpt tumors were significantly correlated with HER2 (p=0.044). In G2 tumors, MCpt correlated with ER (p=0.015) and PR (p=0.038) while in G3 tumors ER correlated with both MCit (p=0.009) and MCpt (p=0.000487) tumors. Conclusion: MCs dynamics are strongly influenced by hormone receptors and HER2 status. MCit increased in aggressive tumor types and is a worse prognostic factor.

show abstract

“…As anyone can imagine, in this hectic conditions and microenvironments, the MC's authentic role in inflammatory tissue and on neoangiogenesis is very hard to describe. Mast cells might be a new target for the adjuvant treatment of various cancers through the selective inhibition of neoangiogenesis, tissue remodeling and tumor promoting mediators [41,42].…”

Section: Resultsmentioning

confidence: 99%

Mast Cells and their Role in Inflammatory and Tumor Tissues

Özdemir¹

2017

MOJI

View full text Add to dashboard Cite

Mast cells are multifunctional cells and they can also have a role as effector factors of the human innate and adaptive immune system. While a number of researchers still assume Mast cells to be augmenters of tumor growth, particularly via their effects on neoplastic angiogenesis; growing clinical and laboratory information also signify that Mast Cells could hamper tumor development. This inhibitory or promoting effect of Mast cells on tumor expansion seems to be depending on numerous relations among Mast cell, tumor cell type and the tumor stroma. Further in vitro and in vivo researches are required to elucidate more the interactions among Mast cells, tumor tissue and other inflammatory cells.

show abstract

Mast cells in breast cancer angiogenesis

Cited by 65 publications

References 32 publications

Mast cells—Good guys with a bad image?

Mast cells—Good guys with a bad image?

Mast Cells as an Indicator and Prognostic Marker in Molecular Subtypes of Breast Cancer

Mast Cells and their Role in Inflammatory and Tumor Tissues

Contact Info

Product

Resources

About