Mast cells in Health and Disease: A Review

Sharada, P; Girish, H. C.; Umadevi, H S; Priya, N K

doi:10.4103/0972-1363.169409

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mast cell accumulation in tumor is probably part of a response to tumor-derived chemoattractant. [46,47] Antitumoral role of mast cells is explained by various mediators that are detrimental to the tumor including cytokines IL-1, IL-4, and IL-6 which induce apoptosis of tumor cells and chondroitin sulfate inhibit metastasis. Mast cells also produce TNF-α, is directly cytotoxic to tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of myeloid cells (tumor-associated tissue eosinophils and mast cells) infiltration in different grades of oral squamous cell carcinoma

Debta

Chaudhary³

et al. 2016

Indian J Med Paediatr Oncol

View full text Add to dashboard Cite

Background:The multifunctional involvement and infiltration of myeloid cells (tumor-associated tissue eosinophils [TATE] and mast cells) can provide a unique opportunity to define relevant effectors functions that may represent novel, therapeutic options for modulation of tumor onset/growth.Aim:Our study aimed to evaluate infiltration of myeloid cells (TATE and Mast cells) infiltration in different grades (WHO grading) of oral squamous cell carcinoma (OSCC).Materials and Methods:Total 30 cases of OSCC were selected for this study. Hematoxylin and eosin stain and toluidine blue special stain, to evaluate TATE and the mast cells infiltration, were used. Three-year follow-up of OSCC cases was done.Result:Among 30 cases, 63.33% cases of OSCC showed TATE-positive and 36.66% cases showed TATE-negative. Regarding mast cells infiltration, 66.66% OSCC cases showed mast cells positive and 33.33% cases did not show significant mast cells infiltration. We found significant association of TATE and mast cells infiltration in OSCC cases. These myeloid cells infiltration significantly associated with age of patients but did not show any significant association with gender, site, and habit of cases. When we compared these cells infiltration with clinical stages and different histological grades of tumor, we found their infiltration is decreasing, from Stages 1 to Stage 3 of tumor and from well to poorly differentiated carcinoma. We have also found the less infiltration of these myeloid in recurrence cases of OSCC.Conclusion:As the infiltration of TATE and mast cells are correlated, along with evaluation of TATE, we should also evaluate the presence of mast cells infiltration in OSCC. The assessment of myeloid cells could become, in the future, useful for therapeutic approaches in this subset of the patient.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of myeloid cells (tumor-associated tissue eosinophils and mast cells) infiltration in different grades of oral squamous cell carcinoma

Debta

Chaudhary³

et al. 2016

Indian J Med Paediatr Oncol

View full text Add to dashboard Cite

show abstract

“…Tumour stroma consists of various inflammatory cells like lymphocytes, macrophages, neutrophils, plasma cells, mast cells and eosinophils (Saraswati et al, 2003, Sharada et al, 2006. Cells of immune system comprised of lymphoid series and myeloid progenitor series cells.…”

Section: Discussionmentioning

confidence: 99%

“…The main functions of mast cells are probably, regulation of vascular functions at the initiation of an inflammatory response and activation of other cells. Mast cells also initiate immediate hypersensitivity reactions, modulate allergic inflammation, and participate in the immune response to parasitic infections (Sharada et al, 2006). Mast cells, when stimulated, can exocytose a fraction of their secretory granules in to the surrounding tissue, a process called degranulation.…”

Section: Introductionmentioning

confidence: 99%