Mast Cells in Periodontal Disease of Individuals With and Without HIV Undergoing Highly Active Antiretroviral Therapy

Segundo, Takeshi Kato; Souto, Giovanna Ribeiro; Costa, Fernando Oliveira; Mesquita, Ricardo Alves

doi:10.1902/jop.2012.120436

Cited by 4 publications

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“…Mast cells are involved in many pathological conditions such as asthma, gingivitis, periodontitis, and oral lichen planus with their numbers and MMPs expression significantly increased in chronic periodontitis. [ 10 ] Thus, mast cell analysis can serve as a useful histological marker for periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Quantitative analysis of mast cell count and density in chronic periodontal disease

Rathod

Raj

Wanikar

2018

J Indian Soc Periodontol

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Background:Mast cells play a crucial role in activation of acquired immune response to inflammatory conditions of periodontal diseases. They promote inflammation by releasing pro-inflammatory mediators and bring about angiogenesis, degeneration of the extracellular matrix, and tissue remodeling. Since there is little literature regarding the role of mast cells in periodontitis, the present study was aimed to evaluate mast cell count (MCC) and density in periodontitis.Materials and Methods:A total of eighty participants, Group I (n = 40) healthy participants and Group II (n = 40) participants with moderate chronic periodontitis, were included in the study. Tissue samples of 5 micron were obtained from each participant and were fixed in 10% formalin. Inflammation assessment was carried out after staining the sections with hematoxylin/eosin (H and E) followed by toluidine blue and mast cells were counted.Results:MCC in healthy group (1.32 ± 0.43) was significantly smaller than periodontitis group (10.28 ± 1.15) and also mast cell density in healthy group (98.08 ± 37.40) was smaller than periodontitis group (803.43 ± 89.94) with P < 0.0001.Conclusions:It could be concluded that participants with chronic periodontitis have a higher MCC and density when compared with healthy participants.

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Section: Discussionmentioning

confidence: 99%

Quantitative analysis of mast cell count and density in chronic periodontal disease

Rathod

Raj

Wanikar

2018

J Indian Soc Periodontol

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“…In a prior analysis of our research group 17 , the results did not demonstrate a statistically significant difference in the mast cell densities in HIV-infected individuals with periodontal disease undergoing HAART in comparison with non-HIV-infected individuals with periodontal disease. It was suggested that this fact may well be the result of the application of HAART in individuals with HIV 17 . Considering the importance of the mast cell in the immune response, it was evaluated the hypothesis of an alteration on the mast cell degranulation in gingival tissue of HIV-infected individuals.…”

Section: Introductionmentioning

confidence: 99%

Mast cell degranulation in periodontal disease from HIV-infected individuals

et al. 2019

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Aim: The objective was to compare the density and degranulation of mast cells on specimens obtained from individuals diagnosed with gingivitis or chronic periodontitis who were either non-HIV-infected or HIV-infected patients treated with highly active antiretroviral therapy (HAART). Methods: Gingival samples were taken from 16 non-HIV-infected individuals and 17 HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. The samples were processed and stained with 0.3 percent o-toluidine blue. Densities (cells/mm²) and percentages of intact and degranulated mast cells were obtained. Results: No statistically significant differences were observed in the mast cell density and the percentage of degranulated mast cells between non-HIV-infected and HIV-infected individuals diagnosed with gingivitis and chronic periodontitis. Mononuclear inflammatory infiltrate was weakly correlated with the percentage of mast cells degranulated for both groups. Conclusions: There are no differences of the density and degranulation of mast cells in gingival tissue between non-HIV-infected and HIV-infected patients undergoing HAART, both groups with diagnosis of gingivitis or chronic periodontitis. This may be a result of the recovery of the immunologic system by HAART treatment.

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SFOT Surgery

Mandelaris

2023

Surgically Facilitated Orthodontic Therapy

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Mast Cells in Periodontal Disease of Individuals With and Without HIV Undergoing Highly Active Antiretroviral Therapy

Abstract: Individuals with HIV undergoing HAART, compared with individuals without HIV, had no statistically significant differences in mast cell densities in gingival tissue.

Cited by 4 publications

References 44 publications

Quantitative analysis of mast cell count and density in chronic periodontal disease

Quantitative analysis of mast cell count and density in chronic periodontal disease

Mast cell degranulation in periodontal disease from HIV-infected individuals

SFOT Surgery

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