Mast cells in testicular lesions

Kollur, Sharanamma M.; Pattankar, V. L.; Hag, I. A. El

doi:10.3109/2000-1967-086

Cited by 8 publications

(3 citation statements)

References 21 publications

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“…Several reports have associated an increased number of MCs with male infertility. 23 – 25 In cases of idiopathic male infertility, Hashimoto et al 26 and Nagai et al 27 demonstrated increased MCs in the lamina propria of STs, and observed a rise in chondroitin sulfate-positive MCs. Hussein et al associated abnormal spermatogenesis with increased numbers of MCs.…”

Section: Discussionmentioning

confidence: 99%

The role of ketotifen in the prevention of testicular damage in rats with experimental unilateral undescended testes

Açıkgöz¹,

Aşçı²,

Aydın³

et al. 2014

DDDT

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The aims of this study conducted on rats were to determine mast cell (MC) proliferation on undescended testes (UDTs); whether there is a correlation between MC proliferation and testicular damage; and whether testicular damage can be prevented with administration of an MC blocker. Sixty-five newborn male rats were divided into three groups. During the neonatal period, unilateral UDTs were experimentally induced in Group 2 and Group 3. The rats in Group 3 were given 1 mg/kg/day ketotifen orally until the end of the study. Groups 2 (n=30) and 3 (n=15) were divided into groups of ten and five rats, respectively, each of which underwent bilateral orchiectomy in either the prepubertal, pubertal, or adult period. Group 1 (n=15) underwent a sham operation followed by bilateral orchiectomy, with five rats in each of the prepubertal, pubertal, and adult periods. Testicular MCs in the interstitial and subtubular areas, biopsy scores, interstitial connective tissue, seminiferous tubule (ST) diameters, and the basement membrane thickness of STs were evaluated. In Group 2 the ST diameters in the UDTs decreased, the number of MCs in the interstitial and subtubular areas increased, ST basement membranes thickened, and spermatogenesis decreased. The number of MCs in the interstitial and subtubular areas of the descended testes increased and spermatogenesis decreased. In Group 3, the number of MCs in the interstitial and subtubular areas decreased. In unilateral UDTs, the number of MCs in the interstitial and subtubular areas increased in both testes. Fibrosis developed in the ST basement membranes and interstitial areas, and spermatogenesis deteriorated. Testicular fibrosis may be prevented with administration of an MC blocker.

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Section: Discussionmentioning

confidence: 99%

The role of ketotifen in the prevention of testicular damage in rats with experimental unilateral undescended testes

Açıkgöz¹,

Aşçı²,

Aydın³

et al. 2014

DDDT

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“…A growing body of evidence indicates association between mastocytosis and male infertility [10][11][12]. It has been reported that increased number of MCs is ascribed to idiopathic male infertilities and spermatogenic disorders [13][14][15].…”

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confidence: 99%

Male Fertility as a Bull’s Eye for Mastocytosis

Jalali¹

2018

GJORM

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Mast cell (MC) as a free cell type can be found in connective and epithelial tissues throughout the body as well as peritoneal and thoracic cavities in rodents [1].The MCs are located in subepithelial areas in connective tissue surrounding blood cells, smooth muscle, mucous and hair follicles and have been detected in all vascularized tissues except for the central nervous system and the retina [2]. The cytoplasm of MC contains 50-200 large granules storing a variety of substances with potent physiological activities including histamine, heparin, serotonin, cytokines, chondroitin sulfate and neutral proteases [3][4][5]. It is well-established that these multi-functional master cells are involved in a wide spectrum of functions including vasodilation, angiogenesis, bacterial and parasite elimination, immune system, vascular and bronchial homeostasis and bone growth, remodeling and mineral homeostasis along with inflammatory, hypersensitivity and fibrotic disorders [2,[6][7][8].Three populations of MCs have been identified based on protease content. The mucosal MC (MCT) only containstryptase, the connective tissue MC (MCTC) contains tryptase, chymase, carboxypeptidase and cathepsin and the third MC type (MCC) has chymase and carboxypeptidase [9].

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“…Diversos trabalhos relacionam a existência de casos de infertilidade humana e espermatogênese anormal com aumento dos mastócitos testiculares. 29,35,36 A secreção dos mastócitos estimula a proliferação de fibroblastos tendo papel chave na fibrose e espessamento da parede dos túbulos seminíferos, característica histológica comum encontrada nos casos de infertilidade masculina. 27,37 O epidídimo apresenta menor número de mastócitos que outros órgãos, 38 O maior número de mastócitos encontrado no epidídimo de ratos alcoólicos difere dos resultados apresentados por Gaytan et al 20 .…”

Section: Discussionunclassified

Mastócitos no lobo ventral da próstata, no epidídimo e no testículo de ratos UChB (consumidores voluntários de etanol a 10%)

Mendes¹

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Mast cells in testicular lesions

Cited by 8 publications

References 21 publications

The role of ketotifen in the prevention of testicular damage in rats with experimental unilateral undescended testes

The role of ketotifen in the prevention of testicular damage in rats with experimental unilateral undescended testes

Male Fertility as a Bull’s Eye for Mastocytosis

Mastócitos no lobo ventral da próstata, no epidídimo e no testículo de ratos UChB (consumidores voluntários de etanol a 10%)

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