Mast cells in the submandibular gland of cat

Histamine was found to be stored in the submandibular gland of the cat mainly in the mast cells. The amine is released from mast cells by compound 48/80 and pilocarpine. This was demonstrated in the in vivo and in vitro experiments and by histological examination. During the physiological stimulation of the gland, via the electrical stimulation of the chorda tympani nerve, significant changes of histamine content were not found. This could be explained by the increased synthesis of histamine during physiological stimulation. The physiological role of histamine in salivary secretion was demonstrated. The similarity between the roles of histamine, mast cells and chromaffine-like cells in salivary and gastric secretion is discussed.

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The role of tissue mast cells in exocrine secretion: Studies in the submandibular gland of the cat

Erjavec

Logonder-Mlinšek

Ozvald

et al. 1983

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The mechanism of histamine release induced by pilocarpine from different tissues: Studies on rat peritoneal mast cells

Erjavec

Ferjan

1994

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Pilocarpine releases histamine from mast cells of cat submandibular gland and rat liver. In the salivary gland, histamine is released into the saliva and venous outflow. Atropine blocks the salivation, but not histamine release from the submandibular gland into the blood. Histamine release from the gland could be due to a direct action of pilocarpine on tissue mast cells or to an indirect action of mediators (acetylcholine and peptides). These hypotheses were further investigated in our present studies on rat peritoneal mast cells. Our results show: (1) histamine release from rat peritoneal mast cells induced by pilocarpine (ED50 = 1.7 x 10(-2) mol/l) occurs at 1000-fold higher concentrations than by substance P (ED50 = 1.7 x 10(-5) mol/l) and in 6.5-fold higher concentrations than by atropine (ED50 = 2.6 x 10(-3) mol/l), (2) pilocarpine injected directly into the rat peritoneal cavity causes histamine release from peritoneal mast cells in 1.8-fold higher concentrations than from isolated rat peritoneal mast cells. These results would support the hypothesis that histamine release from cat submandibular gland is caused by peptidergic co-transmission during the stimulation of the organ.

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The frequency and distribution of mast cells in pleomorphic adenomas of salivary glands

et al. 2004

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Mast cells in the submandibular gland of cat

Cited by 3 publications

References 4 publications

The role of tissue mast cells in exocrine secretion: Studies in the submandibular gland of the cat

The role of tissue mast cells in exocrine secretion: Studies in the submandibular gland of the cat

The mechanism of histamine release induced by pilocarpine from different tissues: Studies on rat peritoneal mast cells

The frequency and distribution of mast cells in pleomorphic adenomas of salivary glands

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