Mast cells in the tubal wall in women using an intrauterine contraceptive device

Sandvei, Roar; Wollen, Anne‐Lone; Flood, Per R.; Anker, Carsten

doi:10.1111/j.1471-0528.1986.tb08064.x

Cited by 9 publications

(11 citation statements)

References 14 publications

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“…It has been estimated that the ectopic pregnancy rate in IUD users is 3-4% in the total of all pregnancies, while in non-IUD users it is 0.8% or the ratio of ectopic to intrauterine pregnancies in IUD users is 1:20 or 30, while in non-IUD users it is 1:300 [11]. Probably the IUD-related pelvic inflammatory disease is responsible for the increased ectopic pregnancy rate [19,20].…”

Section: Discussionmentioning

confidence: 98%

Copper intrauterine contraceptive device and pregnancy rate

et al. 1994

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Between August 1983 and August 1992, 1995 women aged 20-43 years were fitted with 2736 copper intrauterine contraceptive devices (MLCu250, MLCu375, Nova-T, Gravigard, Anticon). Insertion of the IUD was performed during menstruation by a skilled team of gynecologists. The women were instructed to self-check the IUD tail after each menstrual period. All the women were examined after one month and were followed-up every six months. The 1995 acceptors accumulated a total use of 69,350 months. During this period 39 accidental pregnancies occurred (Pearl Index 0.62, cumulative net pregnancy 1.95 per 100 women). Thirty-six pregnancies were intrauterine and three were ectopic. Most of the accidental pregnancies occurred during the first 12 months of use. The pregnancy rate of IUD users was negatively correlated with age. It is concluded that fitting the Cu-IUD intramenstrually, teaching the user to self-check herself and having frequent re-examinations seems to decrease the pregnancy rate in Cu-IUD users.

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Section: Discussionmentioning

confidence: 98%

Copper intrauterine contraceptive device and pregnancy rate

et al. 1994

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“…Meanwhile, as we know, MCs were known to be multifunctional players in local immune system. Uncontrolled augmentations in quantity, and/or activation of MCs can not only change SMC motility, microcirculation and contribute to sensation of pelvic pain or hyperalgesia in EMs [50], but also lead to pregnancy complications, such as miscarriage, tubal infertility and tubal ectopic pregnancy [51,52]. Therefore, impaired MCs-mediated innate immunity (activation or repression) causes associated oviduct dysfunction or pelvic pain/dysmenorrhoea in EMs, involved in oviduct dysmotility, further influences intratubal fertilization process and contributed to EMs-associated fertility problems.…”

Section: Discussionmentioning

confidence: 99%

Telocytes damage in endometriosis‐affected rat oviduct and potential impact on fertility

Yang

Liu

et al. 2014

J Cellular Molecular Medi

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Women with endometriosis (EMs) have unexplained infertility. The recently identified telocytes (TCs) might participate in the maintenance of structural and functional integrity of oviduct tissue, but so far the involvement of TCs in EMs-affected oviduct tissue and potential impact on fertility capacity remain unknown. By an integrated technique of haematoxylin and eosin staining, in situ immunohistochemistry and double-labelled immunofluorescence staining and electron microscopy approach, TCs were studied in the autotransplantation Sprague–Dawley rat model of EMs-affected oviduct tissue and in sham control, respectively, together with determination of iNOS, COX-2, LPO and estradiol. TCs were found in perivascular connective tissue and smooth muscle bundles in sham oviduct, with typical ultrastructural features (a slender piriform/spindle/triangular cell body, and one or more extremely long prolongations, emerged from cell bodies and extend to various directions), and specific immunophenotype of CD34-positive/vimentin-positive/c-kit-negative. However, in EMs-affected oviduct tissue (grade III), extensive ultrastructural damage (degeneration, discontinue, dissolution and destruction), significant decrease or loss of TCs and interstitial fibrosis were observed, together with elevated level of iNOS, COX-2, LPO and estradiol, thus suggestive of inflammation and ischaemia-induced TCs damage. Based on TCs distribution and intercellular connections, we proposed that such damage might be involved in structural and functional abnormalities of oviduct, such as attenuated intercellular signalling and oviduct contractility, impaired immunoregulation and stem cell-mediated tissue repair, 3-D interstitial architectural derangement and tissue fibrosis. Therefore, TCs damage might provide a new explanation and potential target for EMs-induced tubal damage and fertility disorders.

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“…The use of non-hormonal IUD contraceptives results in a local foreign body effect characterized by a significant influx of inflammatory cells including polymorphonuclear leukocytes, mast cells, and macrophages(4–6). IL-1β, a pleiotropic macrophage- derived cytokine, is involved in the inflammatory immune response(41).…”

Section: Discussionmentioning

confidence: 99%

“…Traditionally, influx of inflammatory cells resulting from copper concentrations in the endometrial tissue has been postulated to create a hostile environment for the embryo, thus contributing to the IUD mode of action. (4–7) Timonen and Kosonen investigated copper release from copper-T IUDs and the corrosive lifespan of copper in utero respectively; they observed sustained low pregnancy rates even when the device was approaching the end of the copper releasing lifespan, raising the question as to whether the mode of action can be explained by the release of copper alone(8, 9). …”

Section: Introductionmentioning

confidence: 99%

Decreased endometrial HOXA10 expression associated with use of the copper intrauterine device

Tetrault

Richman

Fei

et al. 2009

Fertility and Sterility

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Objective-To characterize human endometrial HOXA10 expression in patients using copper intrauterine devices (IUD).Design-Case-control study. Setting-Academic medical center Patient(s)-Women using copper IUDInterventions(s)-Immunohistochemical analysis of endometrial HOXA10 expression in biopsies obtained from 24 women using copper Paraguard T380A as well as in biopsies obtained from 10 normal cycling women who were not using IUD or hormonal contraceptives. Main Outcome Measure(s)-Endometrial HOXA10 expression.Result(s)-Endometrial HOXA10 expression was markedly decreased in biopsies obtained from women using IUD contraceptive when compared to controls. The mean H score for endometrial stromal cell HOXA10 expression in biopsies obtained from women using Paraguard IUD was 0.21 compared to 2.2 in the control endometrial biopsies (P<0.001). Endometrial glandular expression of HOXA10 was absent in all IUD users. Conclusion(s)-Decreasedendometrial HOXA10 expression was apparent in women who use a copper IUD. Expression of HOXA10 is essential for endometrial receptivity. A novel mechanism of copper IUD action involves suppression of genes required for endometrial receptivity. The dramatic decrease of endometrial HOXA10 in response to IUD use may contribute to contraceptive efficacy.

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Mast cells in the tubal wall in women using an intrauterine contraceptive device

Cited by 9 publications

References 14 publications

Copper intrauterine contraceptive device and pregnancy rate

Copper intrauterine contraceptive device and pregnancy rate

Telocytes damage in endometriosis‐affected rat oviduct and potential impact on fertility

Decreased endometrial HOXA10 expression associated with use of the copper intrauterine device

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