Mast cells mediate neutrophil recruitment during atherosclerotic plaque progression

Increased Plasma IgE Accelerate Atherosclerosis in Secreted IgM Deficiency

“…Moreover, we have recently shown that neutrophils, which promote atherosclerosis, 19 are recruited in the vessel wall on MC activation. 13 In line with this, we found that the perivascular area of atherosclerotic lesions of Ldlr (dark blue bar) mice that were fed an atherogenic diet for 16 wk (Online Table I …”

The Ins and Outs of Myeloid Cells in Atherosclerosis

“…The initiation and progression of atherosclerosis are mediated by a continuous recruitment of leukocytes to lesions [30, 63]. They release proinflammatory factors, such as chemokines and granular proteins, promoting endothelial cell activation.…”

Mast-Cell-Derived TNF Amplifies CD8+ Dendritic Cell Functionality and CD8+ T Cell Priming

“…However, there is growing evidence for important MC functions in innate and adaptive immune responses (Abraham and St John, 2010). We and others demonstrated MCs to impact on neutrophil recruitment to sites of inflammation (Dudeck et al, 2011a;De Filippo et al, 2013;Weber et al, 2015;Biedermann et al, 2000;Wezel et al, 2015;Wershil et al, 1991;Zhang et al, 1992). In addition to local responses, MCs have been shown to promote the induction of adaptive T cell responses (Dudeck et al, 2011a;Schubert et al, 2015;Heib et al, 2007;Gregory et al, 2005;McLachlan et al, 2003).…”