Mast cells of the human gingiva

Zachrisson, Bjǒurn U.

doi:10.1111/j.1600-0765.1969.tb01945.x

Cited by 33 publications

(5 citation statements)

References 27 publications

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“…Local degranulation of mast cells occurs during the passage of N. braziliensis through the lungs of the rat in the initial phase of infection (Wells 1971), and in the small intestine of the guinea-pig after a challenge infection with Trichostrongylus colubriformis (Rothwell and Dineen 1972). In acute inflammatory conditions in the skin (Mikhail and Miller-Milinska 1964) and gingiva (Zachrisson 1969) of man, mast cell degranulation occurs.…”

Section: Discussionmentioning

confidence: 99%

Boophilus microplus : Cellular Responses to Larval Attachment and Their Relationship to Host Resistance

Schleger¹,

Lincoln²,

McKenna³

et al. 1976

Aust. Jnl. Of Bio. Sci.

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The histology of early feeding lesions of the cattle tick B. microp/us has been studied using 32p labelled larvae to standardize the duration of attachment. Critical studies were made on 3-h lesions in six separate experiments on different groups of British breed animals. Each group consisted of three animals-one previously unexposed to ticks, one of high resistance and one of low resistance.The degree of mast cell disruption, eosinophil concentration and degranulation, and the extent of epidermal vesiculation were all significantly greater at the site of attachment on highly resistant hosts. In previously unexposed animals there was no mobilization of eosinophils nor mast cell breakdown and no epidermal vesiculation.Possible immune mechanisms producing mast cell disruption and the infiltration and concentration of eosinophils are suggested, and the effect of eosinophil degranulation on larval attachment and feeding is discussed.

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Section: Discussionmentioning

confidence: 99%

Boophilus microplus : Cellular Responses to Larval Attachment and Their Relationship to Host Resistance

Schleger¹,

Lincoln²,

McKenna³

et al. 1976

Aust. Jnl. Of Bio. Sci.

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“…MCs were described some time ago in the mucosa of the oral cavity and particularly in human gingiva (Zachrisson, 1967) and experimental gingivitis (Zachrisson, 1969). As in many other locations in the human body, their intrinsic role in the gingiva is still elusive in both normal and pathological conditions.…”

Section: Introductionmentioning

confidence: 99%

Mast cells as key players in periodontal disease

Popovici

Ceauşu

Cîmpean

et al. 2014

ARCH BIOL SCI BELGRA

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Mast cell (MC) active mediators promote inflammation through changes induced in the connective tissue components of human gingiva. The aim of this study was to evaluate the distribution, mast cell density and their relationship with the degree of inflammatory infiltrate in gingiva from patients with periodontal disease. Thirty-nine cases with periodontal disease and 12 cases without significant changes to the gingival mucosa were investigated. MCs were identified on paraffin-embedded specimens by immunohistochemistry using anti-mast cell tryptase. The inflammatory infiltrate was scored from 0 to 3, and the MCs were counted using the hotspot method. Intraepithelial MCs were scored from 0 to 2. We found a significant increase of mast cell density in cases with mild and moderate inflammatory changes, and a slight decrease in patients with severe periodontal disease. We noticed a higher degranulation rate in patients with periodontal disease compared to those with healthy mucosa. Intraepithelial MCs were found in cases with periodontal disease only and were correlated with the severity of the inflammatory lesion. MCs are important cellular components of the early stages of periodontal disease. Contrary to other studies, we found that MC density and activation increases with moderate inflammation but decreases in severe inflammatory lesions. Our data suggest that MCs are key players in the progression of inflammatory lesions of the gingiva. In advanced-stage periodontal disease, intraepithelial MCs apparently play an important role, although their biological significance remains to be fully understood.

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“…Mast cells are present in periapical granulomas, suggesting their roles in the inflammatory mechanisms of these lesions. However, when under excessive stress, the mast cell may degranulate and release its active compounds, which support the inflammatory response [20,21]. The mast cells' presence also plays a crucial role in periapical granulomas due to their implication in the initiation and promotion of angiogenesis, by secreting several potent angiogenic factors, such as heparin, histamine, VEGF and tryptase [22,23].…”

Section: Discussionmentioning

confidence: 99%

Human Periapical Odontogenic Granulomas: Aspects of Microvessel Density (MVD), Heterogeneity of Blood Vessels and Mast Cells Density (MCD)

Roi,

Negruțiu,

Roi

et al. 2023

Biomedicines

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Periapical odontogenic granulomas are among the most encountered pathology that involve the alveolar bone, with severe consequences such as bone resorption, the presence of inflammatory infiltrate and the formation of abnormal vascularization. The present study aimed to quantify the existence of the microvessel density (MVD), mast cell density (MCD) and heterogeneity of the encountered blood vessels. A total of 37 patients diagnosed with odontogenic periapical granulomas were included, and the gender distribution, age and localization of the pathological lesions was assessed. After the surgical removal of the periapical odontogenic granuloma, the collected tissue was fixed in 10% buffered formalin. Primary processing, morphological analysis and immunohistochemical staining was performed in order to characterize the altered tissue. The results outlined the presence of a high number of mast cells, especially in the area of the inflamed tissue; the high heterogeneity of the blood vessels; and increased MVD with positive CD34. The conclusions of the study focus on the key role of the mast cells and their implication in the initiation and development of the angiogenesis process, triggering the inflammatory response of the host. Nevertheless, periapical odontogenic granulomas develop as an inflammatory response to the interaction between the host’s immune system and microbial invasion.

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Mast cells of the human gingiva

Cited by 33 publications

References 27 publications

Boophilus microplus : Cellular Responses to Larval Attachment and Their Relationship to Host Resistance

Boophilus microplus : Cellular Responses to Larval Attachment and Their Relationship to Host Resistance

Mast cells as key players in periodontal disease

Human Periapical Odontogenic Granulomas: Aspects of Microvessel Density (MVD), Heterogeneity of Blood Vessels and Mast Cells Density (MCD)

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