Recent years have witnessed the significant advance in dense retrieval (DR) based on powerful pre-trained language models (PLM). DR models have achieved excellent performance in several benchmark datasets, while they are shown to be not as competitive as traditional sparse retrieval models (e.g., BM25) in a zeroshot retrieval setting. However, in the related literature, there still lacks a detailed and comprehensive study on zero-shot retrieval. In this paper, we present the first thorough examination of the zero-shot capability of DR models. We aim to identify the key factors and analyze how they affect zero-shot retrieval performance. In particular, we discuss the effect of several key factors related to source training set, analyze the potential bias from the target dataset, and review and compare existing zeroshot DR models. Our findings provide important evidence to better understand and develop zero-shot DR models.