Mastication induces long-term increases in blood perfusion of the trigeminal principal nucleus

Viggiano, Andrea; Manara, Renzo; Conforti, Renata; Paccone, Antonella; Secondulfo, Carmine; Lorusso, Letizia; Sbordone, Ludovico; Salle, Francesco Di; Monda, Marcellino; Tedeschi, Gioacchino; Esposito, Fabrizio

doi:10.1016/j.neuroscience.2015.10.017

Cited by 11 publications

(20 citation statements)

References 15 publications

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“…In general, such a network was consistently reported by other studies that adopted similar gum-chewing tasks [ 65 – 70 ] (Table 4 ). Neuroimaging studies further elucidated that both blood perfusion of the trigeminal nucleus and brain activation in somatosensory areas were associated with chewing-side preference [ 66 , 71 ]. Higher masticatory performance was also associated with the individual intrinsic brain signatures, including the greater gray matter volume in the motor area and higher functional connectivity between the cortex and the cerebellum [ 72 ].…”

Section: Introductionmentioning

confidence: 99%

Revisiting the link between cognitive decline and masticatory dysfunction

Lin

2018

BMC Geriatr

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Age-related decline in cognitive functions and dementia are major challenges in geriatric healthcare. Accumulating evidence from clinical, epidemiological and animal research suggests that tooth loss may be a risk factor for the decline of cognitive functions. This issue highlights the role of the brain-stomatognathic axis in geriatric medicine. Whether input from the stomatognathic apparatus can affect the brain remains an open debate. By revisiting the evidence published in the past five years, we argue that the hypothesis regarding the association between cognitive decline and masticatory dysfunction should be carefully interpreted. Most of the available clinical and epidemiological studies present only cross-sectional data. With respect to the prospective studies, important confounding factors, such as nutritional and physical conditions, were not fully controlled for. Animal research has revealed that hippocampal deficits may play key roles in the observed cognitive decline. However, experimental intervention and outcome assessments may not capture the condition of human subjects. Brain neuroimaging research may be suitable for bridging the gap between clinical and animal research, potentially contributing to (a) the clarification of the brain network associated with mastication, (b) the identification of brain imaging markers for exploring the mechanisms underlying long-term changes in masticatory functions, and (c) the elucidation of interactions between mastication and other cognitive-affective processing systems. Three potential models of the brain-stomatognathic axis and relevant hypotheses are summarized, focusing on the sensory feedback mechanisms, the compensation of motor control, and cerebellar deficits. Finally, we highlight four critical aspects of study and experimental design that should be considered in future research: (a) the refinement of the considered behavioral assessments, (b) the inclusion of baseline changes in mental and physical conditions, (c) a prospective experimental design with longitudinal observations, and (d) a precise determination of the effect size of the association between cognitive decline and masticatory dysfunction.Electronic supplementary materialThe online version of this article (10.1186/s12877-017-0693-z) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Revisiting the link between cognitive decline and masticatory dysfunction

Lin

2018

BMC Geriatr

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“…The results indicate that four articles show an association between mastication and the increase in regional cerebral blood flow.…”

Section: Resultsmentioning

confidence: 78%

“…According to the study by Tada and Miura, the zones with the greatest activation during mastication were the frontotemporal cortex, the caudate nucleus and the thalamus, where an increase of over 15% in regional cerebral blood flow was recorded. Moreover, it was previously found that there is a correlation between chewing intensity and blood perfusion in the principal trigeminal nucleus; the authors maintain that an increase in cerebral blood flow increases neuronal activity in the trigeminal nucleus.…”

Section: Resultsmentioning

confidence: 99%

“…All articles selected were 'cross-sectional studies', two of them analysed cerebral blood flow by magnetic resonance imaging ( Table 1). Viggiano et al 6 quantified blood perfusion from the principal trigeminal nucleus after a mastication exercise, whereas Momose et al 7 evaluated the changes in regional cerebral blood flow during mastication. The latter also used positron emission tomography to measure brain activity.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

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Mastication as a protective factor of the cognitive decline in adults: A qualitative systematic review

Chuhuaicura

Días

Arias

et al. 2019

International Dental Journal

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Introduction A relationship between masticatory function and cognition has been reported. It is proposed that mastication changes the blood flow stimulating the perfusion/oxygenation of the brain. This literature review analysed the relation between mastication as a protective factor of the cognitive decline and the changes produced at brain level in adults associated with the brain blood flow. Materials and methods A systematic review was performed according to the ‘Preferred Reporting Items for Systematic Reviews and Meta‐Analyses’ (PRISMA) criteria in PubMed/MEDLINE, Web of Science, Scopus and Embase. Primary studies were included with no limit on the publication date, conducted on humans, and that established a relation between mastication, brain blood flow and cognitive functions in adult patients. Results Nine clinical descriptive studies were selected and qualitatively analysed. The collected data suggest the greatest brain areas activated during mastication were the frontotemporal cortex, the caudate nucleus and the thalamus, revealing a positive correlation between chewing intensity and perfusion of the principal trigeminal nucleus. The increase in cerebral blood flow was measured by a local vasodilator effect resulting in increased neuronal metabolism in the region linked to learning and memory. In addition, partially edentulous participants had a marked prefrontal deactivation when they chewed without a prosthesis and presented a decrease in masticatory activity. Conclusion Masticatory function may act as a protective factor in those patients with cognition impairment and neurodegenerative diseases, suggesting some mechanisms among which is the increase of cerebral blood flow.

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“…Si consideramos que con el paso del tiempo, dentro de las alteraciones que ocurren en el sistema estomatognático, la perdida de dientes es la más frecuente y que además de afectar la calidad de vida, produce alteraciones en la homeostasis del sistema estomatognático (Sáez Carriera et al, 2007), donde se ve afectada la función masticatoria y en la mayoría de los casos estos sujetos deben cambiar su alimentación, escogiendo alimentos blandos, fáciles de masticar, restándole importancia al valor nutricional (Tremayne & Harrison, 2016). Hay evidencia suficiente sobre el impacto que la masticación tiene sobre la activación cerebral; estudios descriptivos en humanos muestran las diferentes áreas del cerebro que son activadas durante la masticación, tales como la corteza sensoriomotora primaria, suplementaria área motora, ínsula, cuerpo estriado, tálamo y cerebelo (Viggiano et al, 2015); este aumento del flujo cerebral influye en mejorar por ejemplo, procesos como el aprendizaje y memoria, pudiendo considerar que la función masticatoria actúa como factor protector en aquellos sujetos con deterioro cognitivo o enfermedades neurodegenerativas (Sesay et al, 2000). Yokoyama et al (2017) correlaciona positivamente la comida moderadamente dura con el aumento del flujo cerebral.…”

Section: Discussionunclassified

Análisis Cinemático de la Masticación de una Granola Prototipo en Contraste con la Masticación de Maní

Farfán

Coaquira-Quispe

Lezcano

et al. 2020

Int. J. Odontostomat.

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RESUMEN: La masticación se ha estudiado desde diferentes puntos de vista, utilizando alimentos de prueba naturales y artificiales. La evidencia es escasa cuando se analizan alimentos a base de cereales, que van desde cereales para el desayuno hasta barras de granola. El investigar este tipo de alimentos, se vuelve importante para entender el comportamiento de la masticación frente a alimentos con diferentes composiciones y texturas, y como estas características pueden influir en el proceso masticatorio. Se analizó la masticación desde un punto de vista cinemático, en sujetos jóvenes dentados. El alimento de prueba utilizado fue granola prototipo y maní, este último se ha estudiado en sujetos con rehabilitación protésica y su consumo se recomienda en esta población. Se analizaron las características cinemáticas de la masticación como numero de ciclos, frecuencia masticatoria, velocidad de masticación de ascenso y descenso, y el área de masticación en los tres planos del espacio. Se relacionaron los movimientos masticatorios con los movimientos mandibulares bordeantes que conformaron el polígono de Posselt, este también se analizó en los tres planos espaciales. En todas las variables analizadas la granola presento valores mayores, excepto en el número de ciclos masticatorios, sólo se encontraron diferencias estadísticamente significativas (p= 0,03) al comparar la velocidad (ascenso y descenso) y el área de masticación en el plano horizontal.

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Mastication induces long-term increases in blood perfusion of the trigeminal principal nucleus

Cited by 11 publications

References 15 publications

Revisiting the link between cognitive decline and masticatory dysfunction

Revisiting the link between cognitive decline and masticatory dysfunction

Mastication as a protective factor of the cognitive decline in adults: A qualitative systematic review

Análisis Cinemático de la Masticación de una Granola Prototipo en Contraste con la Masticación de Maní

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