Masticatory function and cognitive function

Kubo, Kin‐ya; Ichihashi, Yukiko; Kurata, Chika; Iinuma, Mitsuo; Mori, Daisuke; Katayama, Tasuku; Miyake, Hidekazu; Fujiwara, Shu; Tamura, Yasuo

doi:10.2535/ofaj.87.135

Cited by 26 publications

(22 citation statements)

References 75 publications

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“…A number of studies using a variety of behavioural assays, including the Morris water maze [18,19,31-36], passive avoidance [37], and radial arm maze [20,38,39], indicate that long-term soft-diet feeding or extraction of molar teeth results in learning and memory deficits [40]. Recent studies with the Morris water maze demonstrated that mice fed a hard diet required significantly less time to reach the platform than experimental mice and spent significantly more time in the former platform area, suggesting that hard-diet feeding is associated with improved spatial memory [41].…”

Section: Discussionmentioning

confidence: 99%

“…SAMP8 mice reach adult maturity at 6 months of age when learning and memory deficits become apparent in a variety of behavioural tests [42-45] and when reduced masticatory activity accelerates age-related learning and memory decline [40]. Occlusal disharmony also aggravates age-dependent deficits in spatial learning in the Morris water maze [17,46-49]; see [13,40] for recent reviews. Moreover, monkey studies demonstrate that when occlusal disharmony is removed, the associated stressful response disappears [50].…”

Section: Discussionmentioning

confidence: 99%

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Enriched environment and masticatory activity rehabilitation recover spatial memory decline in aged mice

et al. 2013

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BackgroundTo measure the impact of masticatory reduction on learning and memory, previous studies have produced experimental masticatory reduction by modified diet or molar removal. Here we induced spatial learning impairment in mice by reducing masticatory activity and then tested the effect of a combination of environmental enrichment and masticatory rehabilitation in recovering spatial learning at adulthood and in later life. For 6 months (6M) or 18 months (18M), we fed three groups of mice from postnatal day 21 respectively with a hard diet (HD) of pellets; pellets followed by a powdered, soft diet (HD/SD, divided into equal periods); or pellets followed by powder, followed by pellets again (HD/SD/HD, divided into equal periods). To mimic sedentary or active lifestyles, half of the animals from each group were raised from weaning in standard cages (impoverished environment; IE) and the other half in enriched cages (enriched environment; EE). To evaluate spatial learning, we used the Morris water maze.ResultsIE6M-HD/SD mice showed lower learning rates compared with control (IE6M-HD) or masticatory rehabilitated (IE6MHD/SD/HD) animals. Similarly, EE-HD/SD mice independent of age showed lower performance than controls (EE-HD) or rehabilitated mice (EE-HD/SD/HD). However, combined rehabilitation and EE in aged mice improved learning rate up to control levels. Learning rates did not correlate with swim speed.ConclusionsReduction in masticatory activity imposed on mice previously fed a hard diet (HD/SD) impaired spatial learning in the Morris water maze. In adults, masticatory rehabilitation recovered spatial abilities in both sedentary and active mice, and rehabilitation of masticatory activity combined with EE recovered these losses in aged mice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Enriched environment and masticatory activity rehabilitation recover spatial memory decline in aged mice

et al. 2013

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“…amyotrophic sclerosis) and exhibit more rapid aging. These findings suggest that reduced oral function is a risk factor of reduced cognitive function [14][15][16], and appropriate oral stimulation can assist with the prevention of dementia [17].…”

Section: Introductionmentioning

confidence: 88%

Correlation analysis between elderly oral myofunction, oral microorganisms, and cognitive function

Kim¹

2019

Korean Society of Dental Hygiene

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Objectives: This study aimed to analyze the correlation between oral function, oral environment, and brain cognitive function in the elderly. Methods: The subjects were 60 users of senior community center and elderly day care center. The survey was conducted from November to December 2018. Subjects were assessed by oral examination and myofunction test. Oral myofunction was measured using IOPI R and Lip de Cum R . Survey data were analyzed using the statistical programs of PASW Statistics ver. 18.0. Results: Tongue muscle strength and lips muscle strength was higher in males than in females. The tongue and lip strengths were higher in the <81 years old group than the ≥81 years old group. Functional tooth analysis showed that there was a ≥15 teeth group (40.91±7.36) and a <15 teeth group (32.52±7.14).Lip muscle strength analysis showed that the ≥15 teeth group (10.54±3.40) was higher than the <15 teeth group (8.20±2.41, p<0.05). Tongue muscle strength, lumbar muscle strength, and functional tooth number were lower in the elderly subjects with mild cognitive impairment.Cognitive function was significantly correlated with functional tooth number (r=0.386, p<0.001), tongue strength (r=0.478, p<0.001), and lip strength (r=0.281, p<0.05). Tongue strength was significantly correlated with lip strength (r=0.360, p<0.001) and functional tooth number (r=0.633, p<0.001). Lip strength was significantly correlated with functional tooth number (r=0.376, p<0.001). Conclusions: These results showed that age and functional tooth number influenced oral muscle strength and that the number of functional teeth and oral muscle strength were low in the elderly with mild cognitive impairment. Oral myofunction training and oral care program are suggested to improve the quality of life of the elderly.

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“…En múltiples investigaciones realizadas mediante imagenología funcional en seres humanos, se ha encontrado que varias regiones del SNC se activan durante la masticación, estas incluyen a la corteza somatosensorial primaria, la corteza motora primaria, el área motora complementaria, el área premotora, la corteza prefrontal, la ínsula, la corteza parietal, el tálamo, el hipotálamo, el cuerpo estriado, el cerebelo, la corteza entorrinal y el hipocampo 2,5,6,[21][22][23] .…”

Section: Influencia De La Activación Masticatoria Sobre El Sistema Neunclassified

Bases neurocientíficas de la función masticatoria y su efecto sobre el estrés y las funciones cognitivas

Aguirre-Siancas

2017

Rev. chil. neuro-psiquiatr.

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The subtle neuroscientific mechanisms related to chewing evinces its functionality as astimulator of different areas in the neocortex. This paper is a thorough review of the neuroscientific evidence related to the functionality of chewing and its impact on other and more complex processes, with the aim of presenting chewing as a physiological mechanism to counteract stress and ease important cognitive functions. Thus, becoming more visible as a marginal activity to pay attention, especially, within people prone to develop a decline on learning and memory functions.

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Masticatory function and cognitive function

Cited by 26 publications

References 75 publications

Enriched environment and masticatory activity rehabilitation recover spatial memory decline in aged mice

Enriched environment and masticatory activity rehabilitation recover spatial memory decline in aged mice

Correlation analysis between elderly oral myofunction, oral microorganisms, and cognitive function

Bases neurocientíficas de la función masticatoria y su efecto sobre el estrés y las funciones cognitivas

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