Objective: To systematically review the relationship between malocclusions and masticatory performance. In addition, we will perform a qualitative analysis of the methodological soundness of the studies. Materials and Methods: A literature survey was done by applying the Medline database (www. ncbi.nim.nih.gov) in the period from January 1965 to June 2009, using the ''Medical Subject Headings'' term malocclusion crossed with various combinations of the following terms: masticatory performance, masticatory efficiency, and chewing efficiency. The articles were separated into two main topics: (1) the influence of malocclusion treatment (orthognathic surgery) and (2) the influence of malocclusion type and severity. Results: The search strategy used identified 78 articles. After selection according to the inclusion/ exclusion criteria, 12 articles qualified for the final analysis. The research quality and methodological soundness were high in one study, medium in 10 studies, and low in one study. The most serious shortcomings comprised the clinical trials and controlled clinical trials designs with small sample sizes and inadequate description of selection criteria. Lack of method error analysis and the absence of blinding in measurements were other examples of shortcomings. Conclusions: Malocclusions cause decreased masticatory performance, especially as it relates to reduced occlusal contacts area. The influence of malocclusion treatment (orthognathic surgery) on masticatory performance is only measurable 5 years after treatment. (Angle Orthod. 2010;80:981-987.)