MASTOCYTEMIA ASSOCIATED WITH A VISCERAL MAST CELL TUMOR IN A SUMATRAN TIGER (PANTHERA TIGRIS)

Abstract

A 6-yr-old male Sumatran tiger (Panthera tigris) with no significant past clinical history was anesthetized for clinical examination after 5 days of lethargy. Clinically, the animal presented with anorexia, pale mucous membranes, and icterus. Hematologic results indicated moderate anemia and severe thrombocytopenia and showed a circulating population of atypical mast cells. The tiger died during anesthesia. On postmortem examination, abdominal hemorrhage associated with marked diffuse hepato-splenomegaly and mesenteric, hepatic, and splenic lymph node hypertrophy were observed. A visceral mast cell tumor was confirmed by histologic examination and toluidine blue staining, with splenic, hepatic, lymphoid, renal, and pulmonary infiltration. Hematologic, postmortem, and histologic findings were consistent with mastocytemia associated with the splenic form of mast cell tumor described in domestic cats.

Cutaneous and splenic mastocytosis in a juvenile Malayan tiger

“…MCTs are reported rarely in exotic felids as cutaneous or visceral tumors in geriatric animals. 2,4,5,16 To our knowledge, cutaneous MCTs have not been reported in a juvenile exotic felid. The MCTs in this tiger cub are morphologically and behaviorally similar to those reported in domestic kittens, most commonly Siamese, with the exception of the unusually large tumors in the paws and splenic involvement in the tiger cub.…”

Systemic mastocytosis and probable mast cell leukaemia in a koala (Phascolarctos cinereus)

“…Mast cell neoplasia is a rare disease of wildlife . Infrequent cases have been reported in reptiles, amphibians and birds, as well as non‐domestic mammals . This report describes the case of a koala ( Phascolarctos cinereus ) with systemic mastocytosis and probable mast cell leukaemia.…”

“…[1][2][3] Infrequent cases have been reported in reptiles, [3][4][5][6] amphibians 7,8 and birds, 2,9,10 as well as non-domestic mammals. 1,[11][12][13][14][15][16] This report describes the case of a koala (Phascolarctos cinereus) with systemic mastocytosis and probable mast cell leukaemia.…”