Mastocytosis patients' cognitive dysfunctions correlate with the presence of spindle‐shaped mast cells in bone marrow

Spolak-Bobryk, Natalia; Romantowski, Jan; Kujawska-Danecka, Hanna; Niedoszytko, Marek

doi:10.1002/clt2.12093

Cited by 6 publications

(9 citation statements)

References 10 publications

(16 reference statements)

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“…Following a review of the titles and abstracts, 1526 results were excluded for the following reasons: 275 were reviews or metaanalysis, 372 were case reports, 412 involved animal study populations, and the remaining did not align with the study's objective, as they did not report neurological alterations in mastocytosis. We initially selected 24 articles 9 , 10 , 12 , 14 , 15 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 for eligibility assessment. After a full text review, three articles were excluded because the patients in those studies did not have a diagnosis of mastocytosis.…”

Section: Resultsmentioning

confidence: 99%

“… 20 , 21 Additionally, bibliographic references were screened, and three additional articles 13 , 34 , 35 met the inclusion criteria. Consequently, a total of 24 studies 9 , 10 , 12 , 13 , 14 , 15 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 were ultimately selected for inclusion in our review. Figure 1 shows the flow diagram illustrating the study selection process.…”

Section: Resultsmentioning

confidence: 99%

“… 40 Cognitive tests focused on memory 24 , 27 and CI. 13 , 27 In neurological evaluations, only one of the studies utilized the Minimental State Exam, 33 while other authors reviewed the patients' previous diagnoses or complaints. 12 , 26 , 34 , 35 Concerning neuroimaging scans, only two studies performed magnetic resonance imaging, 23 , 31 one of them doing diffusion tensor imaging.…”

Section: Resultsmentioning

confidence: 99%

“…Neuropsychiatric manifestations appear to be influenced controversially by indicators of disease burden. Serum tryptase was negatively correlated with stress and depression scores, 30 but positively correlated with impairment level 41 and reduced quality of life 50 . Headache severity seemed to increase with greater histaminergic symptoms 28 ; however, they were also noted to be associated with antihistaminic treatments 9 .…”

Section: Discussionmentioning

confidence: 99%

“…Histamine appears to have a modulatory effect on some mnemonic systems, but its exact function in memory remains controversial 54 . However, in some studies, all these MC‐derived mediators appeared to be independent of neuropsychiatric symptoms, leading scientists to lean toward the hypothesis that the aggressiveness of mastocytosis, rather than MC activation phenomenon, is the cause behind them 41 . For this reason, IL‐6 has shown promise as a predictor of cognitive dysfunction, which has previously been linked to bone pain and osteoporosis 12 .…”

Section: Discussionmentioning

confidence: 99%

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Cognitive, neuropsychiatric and neurological alterations in mastocytosis: A systematic review

Sagües‐Sesé,

García‐Casares,

Álvarez‐Twose

2023

Clinical & Translational All

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BackgroundMastocytosis manifests with multisystemic symptoms, often involving the nervous system. Numerous cognitive, neuropsychiatric and neurological alterations have been reported in multiple observational studies.MethodsWe performed a qualitative systematic literature review of reported data consulting the electronic databases Medline, Scopus, Web of Science, Cochrane, and BASE until June 2023.ResultsWe selected 24 studies in which the majority showed that a high proportion of mastocytosis patients suffer cognitive, neuropsychiatric and neurological alterations. The most common disorders and estimated ranges of frequency observed in adults were depression (68%–75%), anxiety, high stress or irritability (27%–54%), cognitive impairment (27%–39%, primarily affecting memory skills), and headaches (55%–69%). Attention challenges and learning difficulties were reported in children at a rate of 13%, while neurodevelopmental disorders occurred at rates of 8%–12%. Frequent white abnormalities in mastocytosis patients with concomitant psychocognitive symptoms have been reported although neuroimaging studies have been performed rarely in this population.ConclusionFurther studies with more comprehensive and homogeneous evaluations and neuroimaging and histological analysis should be performed for a better understanding of these manifestations. An earlier detection and proper management of these symptoms could greatly improve the quality of life of these patients.

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