Background: Global Positioning System (GPS) devices are widely used in soccer for monitoring external load indicators (ELi) with the aim of maximizing sports performance, while potentially reducing the risk of injury. The aim of this study was to investigate the ELi differences in players of different playing positions (i.e., central backs, external strikers, fullbacks, midfielders, strikers, wide midfielder) and among different sport-specific tasks.Methods: 1932 observations from 28 semi-professional soccer players (FC Palermo, Italy, age: 25±6 years, height: 183±6 cm, weight: 75.2±7 kg) were collected through GPS devices (Qstarz BT-Q1000EX, 10 Hz) during the season 2019-2020. Participants were monitored during Official Match (OM), Friendly Matches (FM), Small Sided Games (SSG), and Match-Based Exercises (MBE). Metabolic (i.e., metabolic power, percentage of metabolic power > 35w, number of intense actions per minute, distance per minute, passive recovery time per minute) and neuromuscular indicators (i.e., percentage of intense accelerations, percentage of intense decelerations, change of direction per min > 30°) were recorded during each task.Results: ANOVA showed significant differences in ELi between player positions within each task and between tasks (p <0.05). Conclusion: In semi-professional soccer players, different ELis were detected for players’ positions showing the highest values during OM. Coaches should consider the different physical responses to different physical tasks and player position to design the most appropriate training program.