In wireless power transfer (WPT) systems with more than two coils, the intermediary or relay circuits are used to extend the link distance. Thus, to achieve this extension efficiently in terms of power transfer, these relay circuits must have low losses. However, there are several instances in which there are restrictions in reducing the ohmic losses in all the relay circuits of the system. This is the case of biomedical applications where commonly there are size and access restrictions since one of the circuits can be implanted and also in applications using high-temperature superconductor (HTS) coils due to the difficulty in implementing the necessary cooling system for all the coils of the system. Therefore, in these situations, the designer need to choose which relay circuit will be optimized. In this work, it is presented an analysis on the impact that losses in individual relay circuits have on efficiency, and power transfer, of typical four-coil wireless power transfer systems consisting of circuit 1 (transmitter), relay circuits 2 and 3, and circuit 4 (load). It is shown that the losses on relay circuit 2 have greater impact on efficiency, while the losses of relay circuit 3 have a greater impact on power transfer for a given condition. Practical experiments confirm the developed analysis.