Matching geometry and stimulation parameters of electrodes for deep brain stimulation experiments—Numerical considerations

Gimsa, Ulrike; Schreiber, U.; Habel, Beate; Flehr, Jürgen; Rienen, Ursula van; Gimsa, Jan

doi:10.1016/j.jneumeth.2005.06.013

Cited by 49 publications

(48 citation statements)

References 42 publications

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“…Electrical stimulation was delivered via concentric bipolar electrodes (CBASC75; FHC), the detailed electrical properties of which have been described previously (Gimsa et al, 2005(Gimsa et al, , 2006. Electrode integrity was verified by impedance measurement.…”

Section: Methodsmentioning

confidence: 99%

“…Current (0 -500 A), duration (30 -120 min), and laterality (unilateral or bilateral) of stimulation varied by experiment. Charge density, calculated using electrode geometry (McCreery et al, 1990;Gimsa et al, 2005Gimsa et al, , 2006, was kept below 30 C/cm 2 /phase to minimize the risk of stimulation-induced neural injury (McCreery et al, 1990).…”

Section: Methodsmentioning

confidence: 99%

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Stimulation of Entorhinal Cortex Promotes Adult Neurogenesis and Facilitates Spatial Memory

Stone

Teixeira²,

DeVito³

et al. 2011

J. Neurosci.

354

284

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Deep brain stimulation (DBS)is an established therapeutic modality for the treatment of movement disorders and an emerging therapeutic approach for the treatment of disorders of mood and thought. For example, recently we have shown that DBS of the fornix may ameliorate cognitive decline associated with dementia. However, like other applications of DBS, the mechanisms mediating these clinical effects are unknown. As DBS modulates neurophysiological activity in targeted brain regions, DBS might influence cognitive function via activity-dependent regulation of hippocampal neurogenesis. Using stimulation parameters analogous to clinical high-frequency DBS, here we addressed this question in mice. We found that acute stimulation of the entorhinal cortex (EC) transiently promoted proliferation in the dentate gyrus (DG). Cells generated as a consequence of stimulation differentiated into neurons, survived for at least several weeks, and acquired normal dentate granule cell (DGC) morphology. Importantly, stimulation-induced promotion of neurogenesis was limited to the DG and not associated with changes in apoptotic cell death. Using immunohistochemical approaches, we found that, once sufficiently mature, these stimulation-induced neurons integrated into hippocampal circuits supporting water-maze memory. Finally, formation of water-maze memory was facilitated 6 weeks (but not 1 week) after bilateral stimulation of the EC. The delay-dependent nature of these effects matches the maturation-dependent integration of adult-generated DGCs into dentate circuits supporting water-maze memory. Furthermore, because the beneficial effects of EC stimulation were prevented by blocking neurogenesis, this suggests a causal relationship between stimulation-induced promotion of adult neurogenesis and enhanced spatial memory.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Stimulation of Entorhinal Cortex Promotes Adult Neurogenesis and Facilitates Spatial Memory

Stone

Teixeira²,

DeVito³

et al. 2011

J. Neurosci.

354

284

View full text Add to dashboard Cite

show abstract

“…The distribution of the electric potential in the vicinity of a DBS electrode has previously been modelled using isotropic homogenous tissue [8][9][10][11][12][13][14][15][16]. More recently, Butson et al [17] presented a three dimensional (3D) patient-specific method to predict the volume of tissue activated by DBS based on diffusion tensor images (DTI).…”

Section: Introductionmentioning

confidence: 99%

Method for patient-specific finite element modeling and simulation of deep brain stimulation

Åström

Zrinzo

Tisch

et al. 2008

Med Biol Eng Comput

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Deep brain stimulation (DBS) is an established treatment for Parkinson's disease (PD). Success of DBS is highly dependent on electrode location and electrical parametersettings. The aim of this study was to develop a general method for setting up patient-specific 3D computer models of DBS, based on magnetic resonance images, and to demonstrate the use of such models for assessing the position of the electrode contacts and the distribution of the electric field in relation to individual patient anatomy. A software tool was developed for creating finite element DBS-models. The electric field generated by DBS was simulated in one patient and the result was visualized with isolevels and glyphs. The result was evaluated and corresponded well with reported effects and side effects of stimulation. It was demonstrated that patient-specific finite element models and simulations of DBS can be useful for increasing the understanding of the clinical outcome of DBS.

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“…Clinical DBS devices commonly use constant-voltage stimulation, whereas constant-current stimulation guarantees constant field strengths and stimulation efficiency in the surrounding tissue of small animal electrodes by circumventing the effects of impedance alterations at the electrode interface or in the capsule (adventitia) tissue [5]. Studies have demonstrated that current-controlled devices may also improve the therapeutic effects in patients [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Impedance detection of the electrical resistivity of the wound tissue around deep brain stimulation electrodes permits registration of the encapsulation process in a rat model

Badstuebner

Stubbe

Kroeger

et al. 2017

Journal of Electrical Bioimpedance

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An animal model of deep brain stimulation (DBS) was used in in vivo studies of the encapsulation process of custom-made platinum/iridium microelectrodes in the subthalamic nucleus of hemiparkinsonian rats via electrical impedance spectroscopy. Two electrode types with 100-µm bared tips were used: i) a unipolar electrode with a 200-µm diameter and a subcutaneous gold wire counter electrode and ii) a bipolar electrode with two parallelshifted 125-µm wires. Miniaturized current-controlled pulse generators (130 Hz, 200 µA, 60 µs) enabled chronic DBS of the freely moving animals. A phenomenological electrical model enabled recalculation of the resistivity of the wound tissue around the electrodes from daily in vivo recordings of the electrode impedance over two weeks. In contrast to the commonly used 1 kHz impedance, the resistivity is independent of frequency, electrode properties, and current density. It represents the ionic DC properties of the tissue. Significant resistivity changes were detected with a characteristic decrease at approximately the 2nd day after implantation. The maximum resistivity was reached before electrical stimulation was initiated on the 8th day, which resulted in a decrease in resistivity. Compared with the unipolar electrodes, the bipolar electrodes exhibited an increased sensitivity for the tissue resistivity.

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Matching geometry and stimulation parameters of electrodes for deep brain stimulation experiments—Numerical considerations

Cited by 49 publications

References 42 publications

Stimulation of Entorhinal Cortex Promotes Adult Neurogenesis and Facilitates Spatial Memory

Stimulation of Entorhinal Cortex Promotes Adult Neurogenesis and Facilitates Spatial Memory

Method for patient-specific finite element modeling and simulation of deep brain stimulation

Impedance detection of the electrical resistivity of the wound tissue around deep brain stimulation electrodes permits registration of the encapsulation process in a rat model

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